帕金森病磁共振成像研究进展  

Advance of magnetic resonance imaging of Parkinson's disease

作　　者：金莉蓉[1] 黄振[1] 

机构地区：[1]复旦大学附属中山医院神经内科,上海200032

出　　处：《重庆医科大学学报》2017年第6期662-666,共5页Journal of Chongqing Medical University

基　　金：国家自然科学青年基金资助项目(编号:81200973);国家自然科学基金重大研究计划资助项目(编号:91332201)

摘　　要：帕金森病(Parkinson’s disease,PD)是常见的中枢神经系统退行性疾病。发现并研究PD的神经影像学标志物有助于早期诊断、评估疾病状态。随着结构和功能磁共振技术的飞速发展,现有的磁共振序列可检测到PD患者脑内铁过度沉积、弥散异常、血流灌注改变、神经黑色素含量减少、结构和功能连接异常等病理改变。本文将就PD患者不同受累部位及相应的磁共振检测技术进展做一综述。Parkinson＇s disease（PD）is a common neurodegenerative disorder. Discovering and studying the neuroimaging markers of PD helps to diagnose,or assess state of the disease. With the rapid development of structural and functional magnetic resonance imaging（MRI）technology,the existing MRI sequences can detect pathological changes of PD patients,including excessive iron deposition,abnormal water diffusion,blood perfusion changes,decreased neuromelanincontent and structural or functional abnormalities.This article will review current state and progress of MRI technology to detect different parts of brain of PD patients.

关 键 词：帕金森病 磁共振 综述 

分 类 号：R774.6[医药卫生—眼科]