副瘤性神经系统综合征的发病机制和临床诊断进展  

Pathogenesis and clinical advance of paraneoplastic neurological syndromes

作　　者：陈齐鸣[1] 

机构地区：[1]蚌埠医学院第一附属医院神经内科,蚌埠233004

出　　处：《重庆医科大学学报》2017年第6期676-681,共6页Journal of Chongqing Medical University

摘　　要：副瘤性神经系统综合征(paraneoplastic neurological syndromes,PNS)是一种与恶性肿瘤密切关联的神经系统疾病,通常要排除其他原因。由于神经系统的每个层面均可受累,从而可导致神经系统的各部位损害出现广泛的神经系统症状和体征。自从发现特异性抗神经元胞核、胞浆及胞膜自身循环抗体后,对该病的认识及诊断得到很大提高,证实自身免疫作用导致PNS发生。本文就该病的临床表现、临床诊断标准、发病机制及癌肿与自身免疫的相关性作一阐述。Paraneoplastic neurological syndromes（PNS）are diseases defined by the presence of a neurological disorder associated with malignancy and exclusion of other known causes of the neurological dysfunction. Because every level of nervous system is potentially involved in PNS,thereby precipitating a variety of neurological deficits and a broader range of clinical signs and symptoms is often presented. Discovery of circulating autoantibdies specific which recognize nuclear,cytoplasmic and membrane antigens presented in all neurons has revolutionized the diagnosis and understanding of these syndromes and demonstrated a role of the immune system for these patients.In this paper,the clinical manifestations,recommended diagnostic criteria,pathological mechanisms and polymorphisms that liked to both cancer and autoimmunity are discussed.

关 键 词：副瘤性神经系统综合征 恶性肿瘤 自身免疫 

分 类 号：R774.6[医药卫生—眼科]