恩替卡韦治疗慢性乙型肝炎患者外周血免疫球蛋白和补体的变化  

Change in peripheral blood immunoglobubin and complement after administering entecavir in patients with chronic hepatitis B

作　　者：林孟新[1] 郭如意[1] 苏智军[1] 

机构地区：[1]福建医科大学附属泉州市第一医院感染科,泉州362000

出　　处：《重庆医科大学学报》2017年第7期787-789,共3页Journal of Chongqing Medical University

基　　金：泉州市第一医院青年科研课题资助项目(编号:2014-QN-45)

摘　　要：目的:了解恩替卡韦治疗慢性乙型肝炎患者免疫球蛋白及补体的变化。方法:采用流式细胞仪检测95例慢性乙型肝炎患者在使用恩替卡韦治疗前及80例健康对照组外周血免疫球蛋白的变化,采用Beckman-Coulter Immage 800免疫化学系统及其配套试剂测定血清补体C3和C4,用雅培化学发光法检测HBs Ag含量。结果:在治疗6个月结束时,95例患者肝功能明显好转,HBs Ag滴度下降前后对比有统计学意义(P<0.05),26例(27.3%)HBs Ag下降>500 IU/m L;恩替卡韦治疗前后Ig G、Ig M、Ig A水平对比有统计学意义(P<0.05);C3和C4水平在治疗前分别为(0.602±0.112)g/L和(0.113±0.075)g/L,治疗后分别为(1.201±0.156)g/L和(0.196±0.033)g/L(P<0.05)。结论:慢性乙型肝炎患者存在不同程度的细胞免疫功能低下,恩替卡韦治疗后能得到一定程度的纠正。Objective：To investigate the changes of immunoglobubin and complement in peripheral blood after administering entecavir in patients with chronic hepatitis B. Methods ： The changes of immunoglobulins in peripheral blood of ninety-five patients with chronic hepatitis B before and after treatment with entecavir were detected by flow cytometry. Serum complement C3 and C4 were measured by Beckman-Coulter Immage 800 immunochemical system and its kit. HBsAg was detected by Abbott chemiluminescence method. At the same time, 80 cases of healthy controls were enrolled. Results：After six months of entecavir treatment,the liver function of ninety- five patients had significantly improved and the level of HBsAg titer reduced significantly（P〈0.05）. Among them,level of HBsAg titer of twenty-six cases（27.3%） decreased 〉500 IU/mL. The levels of IgG,IgM and IgA were significantly increased after treatment with entecavir,and the loads of serum complement C3 and C4 before and after the therapy of entecavir was （0.602± 0.112） g/L and （0.113 ± 0.075） g/L, （1.201 ± 0.156） g/L and （0.196 ± 0.033） g/L,respeetively（P〈0.05）. Conclusion：The degrees of cellular im- mune function can be low in the patients with chronic hepatitis B, but it will be correlated with the efficacy of entecavir.

关 键 词：慢性乙型病毒性肝炎 恩替卡韦 免疫球蛋白 补体 

分 类 号：R575.1[医药卫生—消化系统]