S期细胞比率与乳腺癌免疫组化中ER PR HER-2表达相关性研究  

Correlation study of S-phase fraction and ER, PR or Her-2 expression in immunohistochemisty of breast cancer

作　　者：张景臣[1] 刘薇[1] 毛大华[2] Zhang Jingchen Liu Wei Mao Dahua(The People＇s Hospital of Zhengzhou City, Zhengzhou 450000, Henan, Chin)

机构地区：[1]郑州人民医院,河南郑州450000 [2]贵阳医学院第一附属医院,贵州贵阳550004

出　　处：《临床心身疾病杂志》2017年第3期10-12,共3页Journal of Clinical Psychosomatic Diseases

基　　金：河南省医学科技攻关计划项目（编号201303219）

摘　　要：目的 探讨乳腺癌细胞S期细胞比率与乳腺癌免疫组化中雌激素受体、孕激素受体、人类表皮生长因子受体2表达的相关性.方法 对135例乳腺癌患者癌灶中雌激素受体、孕激素受体、人类表皮生长因子受体2进行检测,比较不同临床参数、检测结果患者S期细胞比率,分析S期细胞比率高表达与雌激素受体、孕激素受体、人类表皮生长因子受体2的相关性. 结果 不同临床参数患者S期细胞比率比较差异无统计学意义（P〉0.05）,雌激素受体、孕激素受体阴性患者S期细胞比率均显著高于阳性患者（P〈0.01）,S期细胞比率高表达与雌激素受体、孕激素受体有显著相关性（P〈0.05）,与人类表皮生长因子受体2无显著相关性（P〉0.05）.结论 乳腺癌细胞S期细胞比率与雌激素受体、孕激素受体表达显著相关,与人类表皮生长因子受体2表达无显著相关性.Objective To explore the correlation between S-phase fraction （SPF） and ER, PR or HER-2 expression in immunohistochemisty （IHC） of breast cancer.Methods Focal ER, PR and HER-2 were detected in 135 breast cancer patients, SPFs compared among patients with different clinical parameters and detection results, and the correlation of high SPF expression to ER, PR or HER-2 done.Results There were no significant differences in SPSs among patients with different clinical parameters （P〉0.05）, the SPFs were significantly higher in patients with negative ER and PR than in ones with positive （P〈0.01）, SPF high expression was notably related to ER and PR （P〈0.05） and wasn＇t to HER-2 （P〉0.05）.Conclusion SPF is notably related to ER and PR expression and isn＇t to HER-2.

关 键 词：乳腺癌 S期细胞比率 雌激素受体 孕激素受体 人类表皮生长因子受体2 

分 类 号：R737.9[医药卫生—肿瘤]