p53凋亡刺激蛋白2和β-连环蛋白在牙龈鳞状细胞癌中的表达及临床意义  

Expression and clinical significance of apoptotic stimulating protein 2 of p53 and β-catenin in gingival squamous cell carcinoma

作　　者：李甜甜[1,2] 李健学[3] Li Tian-tian Li Jian-xue(School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China Department of Pathology, Lanzhou General Hospital of Lanzhou Commend, Lanzhou 730050, China Department of Stomatology, Lanzhou General Hospital of Lanzhou Commend, Lanzhou 730050, China)

机构地区：[1]兰州大学基础医学院,甘肃兰州730000 [2]兰州军区兰州总医院病理科,甘肃兰州730050 [3]兰州军区兰州总医院口腔科,甘肃兰州730050

出　　处：《兰州大学学报（医学版）》2017年第3期39-42,共4页Journal of Lanzhou University（Medical Sciences）

基　　金：甘肃省自然科学基金项目(1208RJZA263)

摘　　要：目的研究p53凋亡刺激蛋白2(ASPP2)和β-连环蛋白在牙龈鳞状细胞癌(GSCC)组织中的表达及临床意义。方法采用免疫组织化学染色法检测22例GSCC组织切片中癌组织和癌旁组织ASPP2及β-连环蛋白的表达,以及ASPP2和β-连环蛋白的表达与临床病理特征之间的关系。结果在GSCC组织中,ASPP2阳性表达率低于癌旁组织,β-连环蛋白阳性表达率高于癌旁组织(P<0.05);ASPP2的表达与肿瘤病理分级有相关性,β-连环蛋白的表达与TNM分期有相关性(P<0.05);ASPP2和β-连环蛋白的表达呈负相关(r=-0.492,P<0.05)。结论联合检测ASPP2和β-连环蛋白在GSCC组织中的表达,可作为判断GSCC恶性程度和预后的参考指标。Objective To explore the expression and clinical significance of apoptotic stimulating protein 2 of p53（ASPP2） and β-catenin in gingival squamous cell carcinoma（GSCC） tissues.Methods Tissues from cancer and para-cancer from 22 GSCC patients were used to detect expression of ASPP2 and β-catenin by immunohistochemistry,for further exploration of their clinical significance.Results Positive expression of ASPP2 was higher in GSCC tissues than that in para-cancer tissues,while the situation of β-catenin was on the contrary（P〈0.05）.The expression of ASPP2 was associated with the pathological stage,while that ofβ-catenin was associated with the TNM stage（P〈0.05）.The results also suggested that the expression of ASPP2 and β-catenin had a negative correlation（r=-0.492,P〈0.05）.Conclusion ASPP2 and β-catenin were differently expressed between cancer tissues and para-cancer tissues.Expressions of ASPP2 andβ-catenin would be a potent evaluation of the biological behavior and prognosis of GSCC.

关 键 词：牙龈鳞状细胞癌 p53凋亡刺激蛋白2 Β-连环蛋白 免疫组织化学染色 

分 类 号：R739.8[医药卫生—肿瘤]