羟考酮与吗啡片用于中度癌症疼痛患者治疗效果比较  

Comparison of oxycodone hydrochloride sustained-release tablets and morphine tablets in the treatment for moderate cancer pain

作　　者：刘玉华[1] 

机构地区：[1]甘肃省肿瘤医院肿瘤内科,甘肃兰州730050

出　　处：《中南医学科学杂志》2017年第4期374-377,共4页Medical Science Journal of Central South China

基　　金：甘肃省卫生厅计划项目(No:GWGL 2014-30)

摘　　要：目的通过Pain Vision法及NRS、KPS、QOL评分比较中度癌痛患者经过盐酸羟考酮缓释片和吗啡即释片两种不同滴定方式的治疗效果和不良反应。方法回顾性分析60例中度癌痛患者,根据治疗方法不同分为羟考酮组及吗啡组,每组30例。羟考酮组患者进行盐酸羟考酮缓释片直接滴定治疗,吗啡组患者则口服即释吗啡片滴定后转换为盐酸羟考酮缓释片治疗,治疗后比较2组的PD值、NRS、KPS、QOL评分及不良反应情况。结果羟考酮组疼痛缓解率明显高于吗啡组(P<0.05);两组患者24 h、72 h时PD值比较,差异无显著性;两组患者72 h时KPS及QOL评分与24 h相比均得到明显提高(P<0.05);羟考酮组总体不良反应低于吗啡组(P<0.05)。结论恶性肿瘤患者,中度癌性疼痛治疗中,盐酸羟考酮缓释片相较于吗啡片起效快、毒副反应小。Objective To compare the efficacy and safety of sustained-release oxycodone hydrochloride tablets and morphine tablets in the treatment of moderate cancer pain by pain vision system,NRS（Numerical rating scale）,KPS（Karnofsky）,QOL（Quality of Life）.Methods60 patients with moderate cancer pain in our hospital were assigned to two groups.30 cases were given oxycodone hydrochloride sustained-release tablets and 30 cases were given morphine tablets and then converted to oxycodone hydrochloride sustained-release tablets.The differences of PD,NRS,KPS,QOL and side effects were compared between 2 groups.ResultsThe pain control in oxycodone hydrochloride group was significantly higher then morphine group （P〈0.05）.There was no significant difference in PD value between the two groups （P〉0.05）.KPS and QOL scores in both groups were improved significantly after 72 h treatment （P〈0.05）.The incidence of adverse drug reactions in the oxycodone hydrochloride group was lower than morphine group （P〈0.05）.ConclusionCompared with morphine tablets,Oxycodone hydrochloride sustained-release tablets work quickly,with small toxic and side reaction.

关 键 词：盐酸羟考酮缓释片 吗啡即释片 癌性疼痛 

分 类 号：R730.5[医药卫生—肿瘤]