手术切除联合氟尿嘧啶植入剂腹腔放置对进展期胃癌远期复发及恶性分子表达的影响  

Effect of surgical resection combined with intraperitoneal fluorouracil implants placement on the long-term advanced gastric cancer recurrence and malignant molecule expression

作　　者：卢强[1] 邹耀祥[1] 阮旭东[2] 

机构地区：[1]厦门大学附属东南医院普通外科,福建漳州363000 [2]厦门大学附属东南医院肿瘤科,福建漳州363000

出　　处：《海南医学院学报》2017年第10期1355-1358,共4页Journal of Hainan Medical University

基　　金：第一七五医院青年苗圃基金(11Y004)~~

摘　　要：目的:研究手术切除联合氟尿嘧啶植入剂腹腔放置对进展期胃癌远期复发及恶性分子表达的影响。方法:选择在我院就诊的68例进展期胃癌术后复发患者,根据术中5-氟尿嘧啶给药方式不同将进展期胃癌术后复发患者分为植入剂组和对照组。术后1天、1周、2周时,测定肝肾功能指标;复发时,测定血清中肿瘤标志物含量及复发病灶内干细胞相关分子的表达量。结果:组内及组间术后1天、1周、2周时血清ALT、AST、BUN、Scr含量的差异无统计学意义;复发时,植入剂组患者血清中OPN、VEGF、CEA、CA50的含量显著低于对照组,胃癌复发病灶内Lgr5、CD44、Tff2、Musashi-1、Notch1、Wnt、β-catenin的表达量显著低于对照组。结论:手术切除联合氟尿嘧啶植入剂腹腔放置能够降低胃癌复发病灶的恶性程度、抑制肿瘤干细胞的特性。Objective： To study the effect of surgical resection combined with intraperitoneal fluorouracil implants placement on the long-term advanced gastric cancer recurrence and malignant molecule expression.Methods： 68 patients with advanced gastric cancer recurrence who were treated in our hospital between May 2015 and October 2016 were selected, and according to the different methods of intraoperative 5-fluorouracil administration, the patients with advanced gastric cancer recurrence wre divided into implants group and control group.1 day, 1 week and 2 weeks after operation, the liver and kidney function indexes were determined;at recurrence, tumor marker levels in serum as well as stem cell-related molecule expression in recurrent lesions were determined.Results： Differences in serum ALT, AST, BUN and Scr levels were not statistically significant within group and between groups 1 day, 1 week and 2 weeks after operation;at recurrence, serum OPN, VEGF, CEA and CA50 levels of implants group were significantly lower than those of control group, and Lgr5, CD44, Tff2, Musashi-1, Notch1, Wnt and β-catenin expression in recurrent gastric cancer lesions were significantly lower than those of control group.Conclusion： Surgical resection combined with intraperitoneal fluorouracil implants placement can reduce the malignant degree of recurrent gastric cancer lesions and inhibit the characteristics of tumor stem cells.

关 键 词：进展期胃癌 5-氟尿嘧啶植入剂 肿瘤标志物 肿瘤干细胞 

分 类 号：R735.2[医药卫生—肿瘤]