脑梗死介入术后应用依达拉奉联合银杏叶提取物对神经功能的改善作用  

Effect of edaravone combined with Ginkgo biloba extract on neurological function after intervention of cerebral infarction

作　　者：胡向阳[1] 葛英[2] 文世全[3] 

机构地区：[1]绵阳市中心医院急诊科,四川绵阳621000 [2]绵阳市人民医院神经内科,四川绵阳621000 [3]绵阳市中心医院神经内科,四川绵阳621000

出　　处：《海南医学院学报》2017年第10期1424-1426,1430,共4页Journal of Hainan Medical University

基　　金：绵阳市卫生局科研基金资助项目(13M011)~~

摘　　要：目的:研究脑梗死介入术后应用依达拉奉联合银杏叶提取物对神经功能的改善作用。方法:对2013年5月~2016年9月在绵阳市中心医院接受介入治疗的152例急性脑梗死患者进行回顾性分析,并分为干预组和对照组,干预组在介入术后接受常规治疗联合依达拉奉、银杏叶提取物治疗,对照组在介入术后接受常规药物治疗。治疗后3、7、14d时,分离血清并测定神经功能损伤标志分子、氧化应激产物及抗氧化酶、血小板活化指标的含量。结果:治疗后3、7、14d时,干预组患者血清中泛素羧基末端水解酶1(UCH-L1)、胶质纤维酸性蛋白(GFAP)、神经元特异性烯醇化酶(NSE)、S100B蛋白(S100B)、活性氧(ROS)、血小板膜蛋白-140(GMP-140)、PAC-1、CD62p的含量显著低于对照组,CAT、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)的含量显著高于对照组(P<0.05)。结论:脑梗死介入术后应用依达拉奉联合银杏叶提取物能够减轻神经功能损伤、促进神经功能恢复,该作用与减轻氧化应激、抑制血小板活化有关。Objective： To study the effect of edaravone combined with Ginkgo biloba extract on neurological function after interventional therapy of cerebral infarction.Methods： A total of 152 cases of patients with acute cerebral infarction received interventional therapy in Mianyang Central Hospital during May 2013-September 2016 were retrospectively analyzed and divided into intervention group and control group, intervention group received routine treatment combined with edaravone and Ginkgo biloba extract treatment, control group received routine medical treatment after interventional therapy.3 days, 7 days, 14 day after therapy, serum levels of neural function injury markers, oxidative stress products and antioxidant enzymes, platelet activation index were determined.Results： On 3 days, 7 days and 14 days after treatment, serum UCH-L1, GFAP, NSE, S100B, ROS, GMP-140, PAC-1 and CD62p contents of intervention group were significantly lower than the control group, CAT, SOD and GSH-PX content were significantly higher than control group.Conclusions： Edaravone combined with Ginkgo biloba extract can reduce neurological injury and promote neurological function recovery after interventional therapy, this effect is related to the reduction of oxidative stress and inhibition of platelet activation.

关 键 词：脑梗死 依达拉奉 银杏叶提取物 氧化应激 血小板活化 

分 类 号：R743.33[医药卫生—神经病学与精神病学]