急性脑梗死患者血清同型半胱氨酸水平与炎性因子、神经因子及NO代谢的相关性  

Serum homocysteine level in patients with acute cerebral infarction and its correlation with inflammatory factors,nerve factors and NO metabolism

作　　者：李志国[1] 周霞[1] 文贵斌[2] 

机构地区：[1]自贡市第三人民医院神经内科,四川自贡643020 [2]自贡市第四人民医院神经内科,四川自贡643000

出　　处：《海南医学院学报》2017年第10期1431-1433,1437,共4页Journal of Hainan Medical University

基　　金：四川省卫生厅科研项目(150343)~~

摘　　要：目的:探讨急性脑梗死患者血清同型半胱氨酸(Hcy)水平与炎性因子、神经因子及一氧化氮(NO)代谢的相关性。方法:收集急性脑梗死患者118例作为观察组,另取同期在本院进行体检的健康人群50例作为正常对照组。检测两组研究对象血清中Hcy水平差异,并根据观察组Hcy水平中位数进一步将其分为高Hcy、低Hcy组各59例。对比不同Hcy水平急性脑梗死患者血清炎性因子、神经因子及NO代谢指标含量差异。结果:观察组患者血清中Hcy水平高于对照组(P<0.05)。高Hcy组患者血清中炎症因子白介素(IL)-1β、IL-6、IL-17、超敏C-反应蛋白(hs-CRP)的含量均高于低Hcy组患者,神经因子和肽素(Copeptin)、N端前脑钠肽(NT-proBNP)、神经元特异性烯醇化酶(NSE)、S-100B蛋白(S-100B)的含量高于低Hcy组患者,NO代谢指标NO、一氧化氮合酶(NOS)的含量高于低Hcy组患者(P<0.05)。结论:急性脑梗死患者血清Hcy水平增高,且Hcy水平与炎性因子、神经因子及NO代谢直接相关。Objective： To study the serum homocysteine （Hcy） level in patients with acute cerebral infarction and its correlation with inflammatory factors, nerve factors and NO metabolism.Methods： A total of 118 patients with acute cerebral infarction were selected as observation group and 50 healthy volunteers who received physical examination in our hospital during the same period were selected as the normal control group.Serum levels of Hcy in two groups were detected, and the median of Hcy levels in observation group was referred to further divide them into high Hcy group and low Hcy group, 59 cases in each group.Serum contents of inflammatory factors, nerve factors and NO metabolism markers were compared between acute cerebral infarction patients with different levels of Hcy.Results： Serum Hcy level in observation group was higher than that in control group （P＆lt;0.05）.Serum contents of inflammatory factors such as IL-1β, IL-6, IL-17 and hs-CRP in high Hcy group were higher than those in low Hcy group, contents of nerve factors such as Copeptin, NT-proBNP, NSE and S-100B in high Hcy group were higher than those in low Hcy group, and contents of NO metabolism indexes such as NO and NOS in high Hcy group were higher than those in low Hcy group （P＆lt;0.05）.Conclusions： Serum Hcy level increases in patients with acute cerebral infarction, and the level of Hcy is directly related to inflammatory factors, nerve factors and NO metabolism.

关 键 词：急性脑梗死 同型半胱氨酸 炎性因子 神经因子 NO代谢 

分 类 号：R743[医药卫生—神经病学与精神病学]