5-氟尿嘧啶子宫动脉置管注射对侵袭性葡萄胎化疗后血清β-hCG、免疫球蛋白水平及生存时间的影响  

Effects of 5-Fluorouracil Ureteral Injection on β-hCG,Humoral Immunity and Survival Time of Invasive Hydatidiform Mole after Chemotherapy

作　　者：田华[1] 叶青[1] 朱雅静[2] 王红民[3] 王莉[4] TIAN Hur YE Qing ZHU Yajing WANG Hongmin WANG Li(Department of Obstetrics, Shiyan Maternal and Child Health-care Hospital, Shiyan, Hubei, 442051, China Graduate School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, 450052, China The First Affiliated Hospital of Zhengzhou University / Henan Provincial Key Laboratory of Clinical Medicine, Zhengzhou, Henan, 450052, China Depart- ment of Obstetrics and ~cology, Henan Province People＇s Hospital, Zhengzhou, Henan, 450003, China)

机构地区：[1]十堰市妇幼保健院产科,湖北十堰442051 [2]郑州大学基础医学院,河南郑州450052 [3]郑州大学第一附属医院/河南省高等学校临床医学重点学科开放实验室,河南郑州450052 [4]河南省人民医院妇产科,河南郑州450003

出　　处：《肿瘤药学》2017年第3期370-374,共5页Anti-Tumor Pharmacy

摘　　要：目的探讨5-氟尿嘧啶子宫动脉置管注射对侵袭性葡萄胎化疗后血清β-h CG、免疫球蛋白水平及生存时间的影响。方法选择2011年1月至2014年10月本院收治的侵袭性葡萄胎患者80例,随机分为对照组和观察组,每组40例。对照组采用5-氟尿嘧啶全身化疗,观察组行5-氟尿嘧啶子宫动脉置管介入栓塞治疗,比较两组干预前及化疗结束后血清β-h CG水平和免疫球蛋白水平,分析两组的临床疗效和2年生存情况。结果治疗后观察组血清β-h CG水平显著低于对照组(P<0.05),观察组Ig M、Ig G和Ig A水平、疾病治疗有效率、1年及2年生存率均高于对照组,差异有统计学意义(P<0.05)。结论 5-氟尿嘧啶子宫动脉置管局部介入栓塞治疗侵袭性葡萄胎,能有效降低治疗后患者血清β-h CG水平,改善患者体液免疫功能,提高临床治疗效果,延长患者生存时间。Objective To investigate the effect of 5-fluorouracil uterine artery catheterization onβ-hCG, humoral immunity and sur- vival time of patients with invasive hydatidiform mole. Methods 80 patients with invasive hydatidiform mole were collected in our hospital between January 2011 and October 2014. Patients were treated with 5-fluorouracil chemotherapy in the control group and embelization with 5-fluorouracil uterine artery in the observation group. The levels of serum β-hCG and humoral immunoglobulin before and after chemother- apy were compared between the two groups and the clinical therapeutic effects were analyzed. The 1-year and 2-year survival rates of the two groups were calculated. Results The level of serum β-hCG in the observation group was significantly lower than that in the control group （P 〈 0.05）. The IgM, IgG and IgA levels in the observation group were significantly higher than those in the control group （P 〈 0.05）, and the effective rate of the observation group was also significantly higher （P 〈 0.05）. The 1- and 2-year survival rates of the observation group were higher than those of the control group （P 〈 0.05）. Conclusion 5-Fluorouracil uterine artery by catheterization of local invasive embolization for the treatment of invasive hydatidiform mole patients can effectively reduce the level of serum β-hCG in patients after treatment, improve immune function, improve clinical efficacy and prolong survival time.

关 键 词：5-氟尿嘧啶 子宫动脉置管 侵袭性葡萄胎 血清Β-HCG 体液免疫 生存时间 

分 类 号：R737.33[医药卫生—肿瘤]