RASAL2在乳腺癌中的表达及临床意义  

Expression of RASAL2 in breast cancer and its clinical significance

作　　者：穆婧[1] 汤铜[1] 钱波[1] 郑璐[1] 童婷婷[1] 

机构地区：[1]安徽医科大学第二附属医院普外科,合肥230601

出　　处：《安徽医科大学学报》2017年第7期1085-1087,共3页Acta Universitatis Medicinalis Anhui

基　　金：安徽省自然科学基金(编号:1308085QH152);安徽医科大学校科研基金联合资助项目(编号:2015xkj111)

摘　　要：应用免疫组织化学法检测60例乳腺癌组织及其癌旁组织中大鼠肉瘤蛋白活化因子2(RASAL2)的表达情况,分析RASAL2与乳腺癌临床发展及病理特征的相关性。结果显示,RASAL2在乳腺癌组织中的表达明显低于癌旁组织,差异有统计学意义(χ2=25.145,P<0.001)。RASAL2在Luminal B型乳腺癌中的表达明显低于Non-Luminal B型,差异有统计学意义(χ2=4.319,P=0.038)。且RASAL2的表达与雌激素受体、孕激素受体、淋巴结转移、TNM分期和有无脉管侵犯有关(P<0.05)。RASAL2在乳腺癌中低表达,且与乳腺癌的发展和侵袭转移有关。The expression of Ras protein activator like 2 （RASAL2）was detected by immunohistochemistry in 60 samples of breast cancer tissues and adjacent paracancerous tissues. The correlation between RASAL2 expression and clinicopathological characteristics was analyzed. The present data showed that the expression of RASAL2 in breast cancer tissue was significantly lower than that in adjacent paracancerous tissue （ X2 = 25. 145, P 〈 0. 001 ）. The expression of RASAL2 in Luminal B breast cancer was significantly lower than that in Non-Luminal B breast cancer （X2 =4. 319 ,P = 0. 038 ）. The expression level of RASAL2 was correlated with ER, PR expression, lymph node metastasis, TNM stage and vascular invasion （P 〈 0. 05）. The expression of RASAL2 is obviously decreased in breast cancer tissue than in adjacent paracancerous tissue, and its low expression is correlated with the development and metastasis of breast cancer.

关 键 词：乳腺癌 RASAL2 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤]