Regulation of inflammation and tumorigenesis by the FIPE family of phospholipid transfer proteins  

作　　者：Jason R Goldsmith Youhai H Chen 

机构地区：[1]Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA

出　　处：《Cellular & Molecular Immunology》2017年第6期482-487,共6页中国免疫学杂志（英文版）

摘　　要：The TIPE （tumor necrosis factor-a-induced protein 8-like） family are newly described regulators of immunity and tumorigenesis consisting of four highly homologous mammalian proteins： TNFAIP8 （tumor necrosis factor-a-induced protein 8）, TIPE1 （TNFAIP8-1ike 1, or TNFAIP8L1）, TIPE2 （TNFAIP8L2） and TIPE3 （TNFAIP8L3）. They are the only known transfer proteins of the lipid secondary messengers PIP2 （phosphatidylinositol 4,5-bisphosphate） and PIP3 （phosphatidylinositol 3,4,5-trisphosphate）. Cell-surface receptors, such as G-protein-coupled receptors and receptor tyrosine kinases, regulate inflammation and cancer via several signaling pathways, including the nuclear factor （NF）-KB and phosphoinositide-3 kinase （PI3K） pathways, the latter of which is upstream of both Akt and STAT3 activation. An expression analysis in humans demonstrated that the TIPE family is dysregulated in cancer and inflammation, and studies both in mice and in vitro have demonstrated that this family of proteins plays a critical role in tumorigenesis and inflammatory responses. In this review, we summarize the current literature for all four family members, with a special focus on the phenotypic manifestations present in the various knockout murine strains, as well as the related cell signalinR that has been elucidated to date.The TIPE （tumor necrosis factor-a-induced protein 8-like） family are newly described regulators of immunity and tumorigenesis consisting of four highly homologous mammalian proteins： TNFAIP8 （tumor necrosis factor-a-induced protein 8）, TIPE1 （TNFAIP8-1ike 1, or TNFAIP8L1）, TIPE2 （TNFAIP8L2） and TIPE3 （TNFAIP8L3）. They are the only known transfer proteins of the lipid secondary messengers PIP2 （phosphatidylinositol 4,5-bisphosphate） and PIP3 （phosphatidylinositol 3,4,5-trisphosphate）. Cell-surface receptors, such as G-protein-coupled receptors and receptor tyrosine kinases, regulate inflammation and cancer via several signaling pathways, including the nuclear factor （NF）-KB and phosphoinositide-3 kinase （PI3K） pathways, the latter of which is upstream of both Akt and STAT3 activation. An expression analysis in humans demonstrated that the TIPE family is dysregulated in cancer and inflammation, and studies both in mice and in vitro have demonstrated that this family of proteins plays a critical role in tumorigenesis and inflammatory responses. In this review, we summarize the current literature for all four family members, with a special focus on the phenotypic manifestations present in the various knockout murine strains, as well as the related cell signalinR that has been elucidated to date.

关 键 词：INFLAMMATION PI3K TIPE TNFAIP8 tumorigenicity 

分 类 号：Q556[生物学—生物化学] S816.48[农业科学—饲料科学]