双相障碍患者治疗前后血清白介素6(IL-6)等细胞因子水平的变化  

The changes of serum cytokine level in patients with bipolar disorder after treatment

作　　者：钱晓娟[1] 陈国强[2] 周新明[1] 胡风涛[1] 

机构地区：[1]湖北省黄梅县人民医院,黄冈438000 [2]黄冈市中心医院

出　　处：《国际精神病学杂志》2017年第3期401-403,共3页Journal Of International Psychiatry

摘　　要：目的观察双相障碍患者治疗前后IL-6等细胞因子的变化。方法选择2015年1月~2016年12月于我院就诊的双相障碍患者92例,采用YMRS量表、HAMD量评估,分为双相狂躁组(n=64)与双相抑郁组(n=28),并选择健康者30例作为对照组,采用酶联免疫吸附试验检测各组血清细胞因子水平,并进行对比。结果治疗前,三组血清IL-2、IL-1β水平对比差异不显著,无统计学意义(P>0.05);双相狂躁组及双相抑郁组患者的血清IL-6水平显著高于对照组(P<0.05)。治疗后,双相狂躁组患者的IL-6水平、YMRS评分及双相抑郁组患者的IL-6水平、HAMD评分均显著低于治疗前(P<0.05);双相狂躁组与双相抑郁组患者治疗前后的IL-6水平与HAMD、YMRS评分之间对具有正相关(P<0.05)。结论双相障碍患者的发作与血清IL-6水平具有相关性,提示IL-6诱导的免疫功能异常。Objective To observe the changes of serum cytokine level in patients with bipolar disorder after treatment. Methods 92 patients with bipolar disorder from January 2015 - December 2016 in our hospital were selected and divided into bipolar mania group （ n =64 ） and the bipolar depression group （ n =28 ）, and 30 healthy cases as the control group. The level of serum cytokines were detected by enzyme linked immunosorbent assay and compared among three group before and after treatment. Results Before treatment, the serum IL-2, IL-1 levels in three groups had no significant difference （P 〉 0.05 ）, while the serum IL-6 level in both bipolar group were significantly higher than that in control group （P 〈 0.05 ） . After treatment, the serum IL-6 level, YMRS/HAMD score of patients in bipolar mania/de- pression group were significantly decreased, The IL-6 level and YMRS/HAMD score has positive correlation （P 〈 0.05 ） . Conclusion There were the correlation between bipolar and serum IL-6 levels.

关 键 词：双相精神障碍 血清白介素-6 诊断 

分 类 号：R749.4[医药卫生—神经病学与精神病学]