精神分裂症恢复期复发影响因素的研究  

The risk factor of relapse on patients with schizophrenia

作　　者：张红梅[1] 赵占胜[2] 孙志刚[1] 李素水[1] 肖庆国[1] 宋丽华[1] 

机构地区：[1]石家庄市第八医院,石家庄050000 [2]河北医科大学附属第二医院

出　　处：《国际精神病学杂志》2017年第3期411-413,426,共4页Journal Of International Psychiatry

基　　金：石家庄市卫生局课题(编号:131460693)

摘　　要：目的探讨精神分裂症复发的相关影响因素。方法以2012年~2013年河北省石家庄市第八医院诊断为精神分裂症的192名患者为对象,随访3年,了解患者恢复期的复发情况,运用自制的调查问卷收集患者基础资料、临床资料,采用二分类Logistic回归分析精神分裂症复发影响因素。结果192例精神分裂症患者3年内复发93例,复发率48.44%,多因素分析发现男性,家庭支持一般、差,未婚、离婚,偏执型患者,病程<1年,有精神病家族史服药不依从是精神分裂症复发的危险因素。尤其是有精神病家族史(OR=4.837,95%CI:2.514~7.326),服药不依从(OR=3.159,95%CI:1.745~4.467)是精神分裂症复发的主要危险因素。结论精神分裂症患者复发受到遗传、服药依从性、家庭环境、疾病的病程、类型等多种因素的影响,应该针对上述因素来降低精神分裂症患者的复发。Objective To investigate the risk factors of relapse on patients with schizophrenia. Methods The basic information and the clinical relevant information of 192 schizophrenia patients were collected. The risk factors were analyzed by logistic regression model. Results 93 patients relapsed schizophrenia in 3 years and the rate of relapse was 48.44 %. The logistic regression analysis shown sexy, family support, marital status, type and duration of illness, family history of Schizophrenia, treatment compliance were risk factors of relapse of schizophrenia, especially family history of Schizophrenia （ OR=4.837, 95 %CI： 2.514 ～ 7.326 ） and treatment compliance （ OR=3.159, 95 % CI： 1.745 ～ 4.467 ） were the most main risk factors. Conclusion There were many factors to influence the relapse of schizophrenia. The results suggest community follow up management for schizophrenia, strengthen treatment compliance and family support were useful for preventing relapse of schizophrenia.

关 键 词：精神分裂症 复发 影响因素 

分 类 号：R749.3[医药卫生—神经病学与精神病学]