外泌体装载的微小RNA及其在肿瘤中的作用  

Exosomal microRNAs and their roles in tumors

作　　者：朱栋炜 王运刚[1] 夏雪莉 王胜军[1] Zhu Dongwei Wang Yungang Xia Xueli Wang Shengjun(Institute of Immunology, Jiangsu University Medical Colleg Key Laboratory of Laboratory Medicine of Jiangsu Province, Zhenjiang 212013, China)

机构地区：[1]江苏大学医学院免疫学研究所江苏省检验医学重点实验室,镇江212013

出　　处：《国际肿瘤学杂志》2017年第6期438-441,共4页Journal of International Oncology

基　　金：国家自然科学基金（31470881）;江苏省大学生创新创业计划（201610299053Y）;江苏省研究生科研创新计划（KYLX16_0920）

摘　　要：外泌体中含有多种脂质、蛋白质、微小RNA（miRNA）等成分，并能将其装载的物质运输至受体细胞而发挥生物学作用。外泌体装载的miRNA在肿瘤发生发展中发挥重要作用，与肿瘤的生长、转移、抗药性、免疫调节密切相关。外泌体及其装载的miRNA可以作为肿瘤转移和预后的参考指标，并为肿瘤的治疗提供新的靶点。Exosomes contain many components including variety kinds of lipids, proteins, microRNAs （miRNAs） and so on. They can transport their loaded substances to the recipient cells and play a role of bio- logy. Exosomal miRNAs play important roles in the occurrence and development of tumors, and they are closely related to the tumor growth, metastasis, drug resistance and immune regulation. Exosomes and exosomal miRNAs can be served as reference indexes for tumor metastasis and prognosis, which provide new targets for tumor therapy.

关 键 词：肿瘤 微RNAS 外泌体 

分 类 号：R730.2[医药卫生—肿瘤]