维泰醇和维康醇的抗肿瘤效应  

Anti-cancer effects of Alternoi and Alteronol on human cancers

作　　者：刘丽华[1] 李本义[2] Liu Lihua Li Benyi(Department of Laboratory Medicine, Shaoxing University School of Medicine, Shaoxing 312000, China)

机构地区：[1]绍兴文理学院医学院医学检验学系,312000 [2]三峡大学人民医院细胞治疗研究所

出　　处：《国际肿瘤学杂志》2017年第6期452-455,共4页Journal of International Oncology

基　　金：国家自然科学基金（81172427）

摘　　要：维泰醇和维康醇是从真菌诱变株的菌丝体中提取纯化的单体化合物，近年的体外和体内实验研究证实它们具有特异性抗肿瘤功效。体外实验研究表明，它们可以抑制多种肿瘤包括前列腺癌、骨肉瘤、黑色素瘤的细胞分裂和增殖，改变细胞周期蛋白表达水平而引起细胞周期停滞，阻断肿瘤细胞浸润和转移，减少新生血管形成，降低肿瘤细胞中Bcl-2等促进细胞存活蛋白的表达以及激发细胞内氧自由基水平等导致细胞凋亡，但是对良性细胞没有显著的致死效应。动物实验表明，这两种化合物能显著抑制多种人类肿瘤的异植瘤生长，而对正常组织器官的不良反应较小，有望开发成为新型抗肿瘤药物。Alternol and Alteronol are two small chemical compounds purified from a mutant fungal. The in vitro and in vivo experimental studies have confirmed their potent anti-cancer effect. In vitro studies show that they can inhibit cell division and proliferation of a variety of tumors including prostate cancer, osteosarcoma and melanoma. They exert their anti-cancer effects by attenuating cell cycle protein expression and causing cell cycle arrest, suppressing tumor cell invasion and metastasis, reducing new blood vessel formation, decreasing the expression of anti-apoptotic proteins Bcl-2 in malignant cells, and stimulating oxygen free radical accumula- tion. However, there is no significant cytotoxic effect on benign cells. Animal experiments show that these two compounds significantly inhibit xenograft growth derived from a variety of human malignant tumors, while there is no obvious side effect on normal tissue or organs. In conclusion, these two compounds are worthy to be deve- loped as novel anti-cancer drugs.

关 键 词：肿瘤 细胞凋亡 细胞周期 维泰醇 维康醇 

分 类 号：R73-3[医药卫生—肿瘤]