抗血管生成治疗在食管癌放疗中的应用  

Application of anti-angiogenesis therapy in the radiotherapy of esophageal cancer

作　　者：封悦[1] 于静萍[1] 汪建林[1] Feng Yue Yu Jing- ping Wang Jianlin(Department of Radiation Oncology, Changzhou Second People＇s Hospital Affiliated to Nan- ring Medical University, Changzhou 213003, China)

机构地区：[1]南京医科大学附属常州第二人民医院放疗科,常州213003

出　　处：《国际肿瘤学杂志》2017年第6期468-471,共4页Journal of International Oncology

基　　金：常州市高层次卫生人才培养计划（2016C2BJ007）;常州市科技支撑社会发展项目（CE20125021、CE20165024）;常州市科技局应用基础研究项目（CJ20159050）;江苏省卫生厅指导性科研项目（Z201220）;常州市卫生局重大项目（ZD201105）

摘　　要：放疗是食管癌非手术治疗的重要手段，5年生存率仅维持在20％～40％。近年来研究发现，抗血管生成治疗不仅可以直接抑制肿瘤的营养摄取，还可以通过使肿瘤血管正常化改善肿瘤组织的乏氧状态从而增强肿瘤细胞的放射敏感性，有望成为提高食管癌放疗疗效的有效方法。Radiotherapy is the principle method of non-surgical treatment for esophageal cancer. The 5-year survival rate ranges from 20% to 40%. In recent years, the studies have found that anti-angiogenesis therapy can not only directly inhibit tumor nutritional intake, but also turn around tumor hypoxia by normalizing tumor vessels so as to enhance the radio-sensitivity of tumor cells, which is expected to become an effective way to improve the curative effect of esophageal cancer radiotherapy.

关 键 词：食管肿瘤 放射疗法 血管生成抑制剂 

分 类 号：R735.1[医药卫生—肿瘤]