Aberrant expression of genes and proteins in pterygium and their implications in the pathogenesis  

作　　者：Qing-Yang Feng Zi-Xuan Hu Xi-Ling Song Hong-Wei Pan Qing-Yang Feng;Zi-Xuan Hu;Xi-Ling Song;Hong-Wei Pan(Department of Ophthalmology,the First Affiliated Hospital of Jinan University;Department of Public Health and Preventive Medicine,Jinan University;Institute of Ophthalmology,School of Medicine,Jinan University)

机构地区：[1]Department of Ophthalmology, the First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong Province, China [2]Department of Public Health and Preventive Medicine, Jinan University, Guangzhou 510632, Guangdong Province, China [3]Institute of Ophthalmology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong Province, China

出　　处：《International Journal of Ophthalmology(English edition)》2017年第6期973-981,共9页国际眼科杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.81570814);Natural Science Foundation of Guangdong Province,China(No.2014A030313363)

摘　　要：Pterygium is a common ocular surface disease induced by a variety of factors. The exact pathogenesis of pterygium remains unclear. Numbers of genes and proteins are discovered in pterygium and they function differently in the occurrence and development of this disease. We searched the Web of Science and PubMed throughout history for literatures about the subject. The keywords we used contain pterygium, gene, protein, angiogenesis, fibrosis, proliferation, inflammation, pathogenesis and therapy. In this review, we summarize the aberrant expression of a range of genes and proteins in pterygium compared with normal conjunctiva or cornea, including growth factors, matrix metalloproteinases and tissue inhibitors of mefalloproteinases, interleukins, tumor suppressor genes, proliferation related proteins, apoptosis related proteins, cell adhesion molecules, extracellular matrix proteins, heat shock proteins and tight junction proteins. We illustrate their possible mechanisms in the pathogenesis of pterygium as well as the related intervention based on them for pterygium therapy.Pterygium is a common ocular surface disease induced by a variety of factors. The exact pathogenesis of pterygium remains unclear. Numbers of genes and proteins are discovered in pterygium and they function differently in the occurrence and development of this disease. We searched the Web of Science and PubMed throughout history for literatures about the subject. The keywords we used contain pterygium, gene, protein, angiogenesis, fibrosis, proliferation, inflammation, pathogenesis and therapy. In this review, we summarize the aberrant expression of a range of genes and proteins in pterygium compared with normal conjunctiva or cornea, including growth factors, matrix metalloproteinases and tissue inhibitors of mefalloproteinases, interleukins, tumor suppressor genes, proliferation related proteins, apoptosis related proteins, cell adhesion molecules, extracellular matrix proteins, heat shock proteins and tight junction proteins. We illustrate their possible mechanisms in the pathogenesis of pterygium as well as the related intervention based on them for pterygium therapy.

关 键 词：PTERYGIUM growth factors MATRIXMETALLOPROTEINASES tissue inhibitors of metalloproteinases INTERLEUKINS tumor suppressor genes proliferation andapoptosis cell adhesion molecules extmcellular matrix proteins 

分 类 号：R777.33[医药卫生—眼科]