HLA与SLE发病机制相关性研究进展  

Progress of HLA with SLE Pathogenesis

作　　者：孙景英[1] 黄贺[1] 杜文辉[1] 孙良丹[1] 汤华阳[1] 张学军[1] 

机构地区：[1]安徽医科大学第一附属医院皮肤性病科/皮肤病研究所,安徽合肥230032

出　　处：《中国皮肤性病学杂志》2017年第7期803-805,808,共4页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金(81371722)

摘　　要：系统性红斑狼疮(systemic lupus erythematosus,SLE)的发病机制研究主要集中在遗传、免疫及环境等方面。HLA系统是目前已知人体最复杂的遗传多态系统,与SLE发病机制密切相关。不同的HLA等位基因和分子分别与患者发病年龄、性别、妊娠、器官损害及实验室检查等相关。本文主要综述MHC多态性及等位基因变异与SLE发病机制方面的相关性研究进展。The mechanisms of systemic lupus erythematosus （SLE） mainly focus on genetic, immunological and environmental factors. HLA is the most complex human genetic polymorphism system, and is closely related with SLE pathogenesis. Different HLA alleles and molecules is associated with age, sex, organ damage, examination and so on. In this article we mainly conclude the relationship between MHC polymorphism and pathogenesis of SLE.

关 键 词：红斑狼疮 HLA 易感性 等位基因 

分 类 号：R593.241[医药卫生—内科学]