嗜酸粒细胞与颅内动脉瘤的相关性  

Relationship between eosinophil count and intracranial aneurysm

作　　者：杜君[1] 王永红[1,2] 李永强[1,2] 范潇男 

机构地区：[1]重庆医科大学附属第一医院神经内科重庆市神经病学重点实验室,重庆400016 [2]重庆医科大学附属第一医院健康体检部,重庆400016

出　　处：《西安交通大学学报（医学版）》2017年第4期622-624,F0003,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：重庆市科技惠民计划(No.CSTC2015JCSF10012)~~

摘　　要：目的探讨嗜酸粒细胞与颅内动脉瘤(IA)的相关性。方法回顾性分析我院2014年1月至2015年12月住院的79例IA患者和65例对照组的外周血嗜酸粒细胞水平及相关临床资料,应用Logistics回归分析IA形成的相关危险因素。结果与对照组相比,IA患者嗜酸粒细胞、血小板计数明显升高[(0.18±0.12)109/L vs.(0.12±0.09)109/L;(196.44±57.33)109/L vs.(178.80±47.23)109/L,P均<0.05],血小板分布宽度、平均血小板体积则降低[(13.95±3.332)fL vs.(15.30±3.5)fL;(11.02±1.73)fL vs.(11.66±1.31)fL,P均<0.05];多因素Logistics回归分析显示嗜酸粒细胞是IA的独立危险因素。结论嗜酸粒细胞升高是IA形成的独立危险因素。Objective To assess the relationship between eosinophil count and intracranial aneurysm （IA）. Methods For the retrospective study, we collected data of the count of eosinophils obtained from the peripheral blood samples and other clinical data of 79 patients with IA admitted to our hospital between January 2014 and December 2015 and 65 healthy people as control group. Risk factors for IA were analyzed by multivariate Logistics regression analysis. Results Clinical characteristics were comparable between the two groups （P 〉 0. 05）. Compared with those in the control group, eosinophil and platelet counts in IA group were significantly higher [（0.18±0.12）10^9/L vs. （0.12±0.09）10^9/L; （196.44±57.33）10^9/L vs. （178.80±47.23）10^9/L, respectively; all P〈0. 051, while platelet distribution width （PDW） and mean platelet volume （MPV） were lower [（13.95±3. 332） fL vs. （15.30±3.5）fL; （11.02±1.73）fL vs. （11.66±1.31）fL, respectively; all P〈0.05）. Logistic regression analysis indicated that eosinophil was the independent risk factor for IA. Conclusion Our study demonstrated that increased eosinophil count is the independent risk factor for IA.

关 键 词：颅内动脉瘤 嗜酸粒细胞 炎症 白细胞 

分 类 号：R743.35[医药卫生—神经病学与精神病学]