妇科恶性肿瘤合并癌性腹水患者应用腹腔热灌注化疗的疗效观察  

Clinical Observation of Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Gynecological Malignant Tumor Complicated with Malignant Seroperitoneum

作　　者：董学彩[1] 杨静[1] 段树锋[1] 

机构地区：[1]新乡市中心医院妇瘤科,河南新乡453000

出　　处：《肿瘤基础与临床》2017年第3期206-209,共4页journal of basic and clinical oncology

摘　　要：目的观察妇科恶性肿瘤合并癌性腹水患者应用腹腔热灌注化疗的疗效。方法选取60例妇科恶性肿瘤伴有癌性腹水患者,给予体外循环热灌注化疗后,观察患者恶性腹水量及相关肿瘤标志物的情况。结果 16例患者腹水减少程度高于90.00%,37例患者腹水减少程度高于50.00%,治疗总有效率为88.33%;治疗后患者血红蛋白水平及腹水最大直径均优于治疗前(P均<0.05),而白细胞计数及血清白蛋白水平均未见明显改变(P均>0.05);相关肿瘤标志物水平均较治疗前降低(P均<0.05)。不良反应较轻,仅有11.67%患者出现恶心、呕吐等不良反应。结论妇科恶性肿瘤合并癌性腹水患者应用腹腔热灌注化疗的疗效较为理想,安全性高,且患者耐受性较佳,临床上值得进一步推广和应用。Objective To observe the curative effects of hyperthermic intraperitnneal ehemotherapy in the treat- ment of gynecological maligzmnt tumor eomplieated with malignant seroperitoneum. Methods Sixty cases of gyneco- logical malignant tumor complicated with malignant seroperitoneum were selected, and the changes in volume of se- roperitoneum and tumor markers were observed after extraeorporeal circulation hyperthermie intraperitoneal chemo- therapy. Results The degree of reduction in the amount of seroperitoneum was significantly higher than 90.00% in the cases ,higher than 50.00% in the 37 cases, and the total effective rate was 88.33% ; after treatment,the hemo- globin content and the maximum diameter of seroperitoneum were better than before treatment （ P 〈 0.05）, white the white blood-cell count and serum albumin showed no significant difference （ P 〉 0.05 ） ; the levels of tumor＇ markers were lower before treatment （P 〈 0.05） ; only 11.67% of patients had nausea and vomiting. Conclusion lntraperitoneal hyperthermic chemotherapy in the treatment of gynecological malignant tumor eomplieated with malignant seroperitoneum has obvious effect,and has the high safety and tolerance.

关 键 词：恶性肿瘤 癌性腹水 腹腔热灌注化疗 肿瘤标志物 

分 类 号：R737.3[医药卫生—肿瘤] R730.6[医药卫生—临床医学]