杏灵分散片对脑梗死患者颈动脉粥样硬化程度和血清炎症因子的影响  

Effect of the Xingling dispersible tablet on carotid atherosclerotic and inflammatory factors in patients with cerebral infarction

作　　者：陈勇军[1] 张平[1] 曹琳[1] 李欣[1] 王灿[1] 蒋莉[1] 

机构地区：[1]南华大学附属南华医院神经内科,湖南省衡阳市421002

出　　处：《中国动脉硬化杂志》2017年第7期719-722,共4页Chinese Journal of Arteriosclerosis

摘　　要：目的观察杏灵分散片对脑梗死患者颈动脉粥样硬化程度和血清炎症因子水平的影响,及美国国立卫生研究院卒中量表评分(NIHSS)改善情况,以探讨杏灵分散片治疗价值。方法选择98例伴有颈动脉粥样硬化斑块的脑梗死患者,随机分为常规治疗组和杏灵分散片组,杏灵分散片组在常规治疗的基础上加服杏灵分散片,疗程3个月,观察两组治疗前后NIHSS评分、颈总动脉粥样硬化斑块面积和颈动脉内膜中膜厚度(IMT)的变化,同时观察血清C反应蛋白(CRP)、同型半胱氨酸(Hcy)和白细胞介素1β(IL-1β)的变化。结果治疗前杏灵分散片组及常规治疗组NIHSS评分、斑块面积和IMT比较无明显差异(P>0.05),治疗后均明显降低(P<0.001);杏灵分散片组治疗后NIHSS评分、斑块面积和IMT小于常规治疗组治疗后(P<0.001)。两组CRP、Hcy和IL-1β治疗前无明显差异(P>0.05),治疗后均较治疗前下降(P<0.001);杏灵分散片组治疗后CRP、Hcy和IL-1β均低于常规治疗组治疗后(P<0.001)。结论杏灵分散片可能通过抑制炎症作用,延缓颈动脉粥样硬化的进展,达到改善神经功能缺损的作用。Aim To observe the effect of Xingling dispersible tablets on carotid atherosclerotic plaque, inflam- matory factors and National Institutes of Health Stroke Scale （NIHSS） in patients with cerebral infarction, and to explore its therapeutic value. Methods 98 patients with cerebral infarction with carotid atherosclerotic plaque were randomly divided into control group and treatment group. On the basis of the control group, the treatment group was treated with Xin-gling dispersible tablets for 3 months. NIHSS, carotid atherosclerotie plaque area and carotid intima-media thickness （IMT） were observed before and after treatment, and the changes of serum C-reactive protein （ CRP ） , homocysteine （Hcy） and interleukin-1β （IL-1β） were also measured. Results There was no significant difference before treatment in the NIHSS score, plaque area and IMT between the treatment group and the control group （P〉0.05）, but significantly decreased after treatment （P〈 0. 001 ）. Mter treatment, the NIHSS score, plaque area and IMT were lower in the treatment group than those in the control group （ P〈0.001 ）. There was no significant difference in the levels of CRP, Hcy and IL-1β between the two groups before treatment （P〉0.05）, but significantly decreased after treatment （P〈0.001）. After treatment, CRP, Hcy and IL-1β in the treatment group were lower than those in the control group （P〈0.001） . Conclusion Xingling dispersible tablets may inhibit the inflammation and delay the progress of carotid atherosclerosis, so as to improve the neurological deficit.

关 键 词：杏灵分散片 脑梗死 颈动脉粥样硬化 炎症因子 美国国立卫生研究院卒中量表 

分 类 号：R743.3[医药卫生—神经病学与精神病学]