喹硫平治疗脑血管病所致精神障碍的疗效及不良反应  

Curative effect and adverse reactions of quetiapine in the treatment of cerebrovascular disease induced mental disorder

作　　者：张薇[1] 刘岱岳[1] 

机构地区：[1]江门市第二人民医院神经内科,529000

出　　处：《中国实用医药》2017年第17期119-120,共2页China Practical Medicine

摘　　要：目的研究喹硫平治疗脑血管病所致精神障碍的疗效及安全性。方法 90例脑血管所致精神障碍患者,随机分成对照组和观察组,各45例。对照组患者给予氟哌啶醇治疗,观察组患者给予喹硫平治疗,对比两组患者的治疗效果、不良反应发生率。结果观察组患者的总有效率为95.56%,与对照组患者的93.33%对比,差异无统计学意义(χ~2=0.212,P>0.05)。观察组患者治疗期间的不良反应发生率为4.44%,低于对照组患者的17.78%,差异有统计学意义(χ~2=4.050,P<0.05)。结论喹硫平治疗脑血管所致精神障碍效果确切,且安全性高,值得在临床上推广应用。Objective To study the curative effect and safety of quetiapine in the treatment of cerebrovascular disease induced mental disorder. Methods A total of 90 cerebrovascular disease induced mental disorder patient were randomly divided into control group and observation group, with 45 cases in each group. The control group received haloperidol for treatment, and the observation group received quetiapine for treatment. Comparison were made on therapeutic effect, incidence of adverse reactions in two groups. Results The observation group had total effective rate as 95.56%, which was 93.33% in the control group, and their difference had no statistical significance （X^2=0.212, P〉0.05）. The observation group had lower incidence of adverse reactions as 4.44% than 17.78% in the control group, and th difference had statistical significance （X^2=04.050, P〈0.05）. Conclusion Quetiapine is effective and safe in the treatment of cerebrovascular disease induced mental disorder, and it is worthy of clinical application.

关 键 词：喹硫平 脑血管病 精神障碍 氟哌啶醇 不良反应 

分 类 号：R749.13[医药卫生—神经病学与精神病学]