息肉状脉络膜血管病变患者血清中常见趋化因子的变化  

Expression of Chemokine in Serum of Polypoidal Choroidal Vasculopathy

作　　者：张亚芳[1] 操盛春[1] 张晓斌[1] 李青春[1] 胡彩平[1] 吴开力[2] 文峰[2] 李岱[1] 

机构地区：[1]湖北科技学院,湖北咸宁437100 [2]中山大学中山眼科中心

出　　处：《湖北科技学院学报（医学版）》2017年第3期200-202,共3页Journal of Hubei University of Science and Technology(Medical Sciences)

基　　金：爱尔眼科医院集团科研基金项(AF141D);湖北科技学院临床医学重点(培育)学科专项(LCZX201504)

摘　　要：目的检测息肉状脉络膜血管病变(PCV)患者血清中嗜酸性粒细胞活化趋化因子(Eotaxin)、生长相关蛋白(GRO-α)、白介素-8(IL-8)、干扰素诱导蛋白-10(IP-10)、单核细胞趋化蛋白-1(MCP-1)及调剂活化正常T细胞表达与分泌的趋化因子(RANTES)的表达,为进一步探讨PCV的发病机制提供依据。方法采集30例PCV患者血清,并以35例无眼底疾病的白内障患者血清作为正常对照组,应用多因子检测试剂盒对两组血清中的Eotaxin、GRO-α、IL-8、IP-10、MCP-1及RANTES的表达进行检测,分析各因子在两组血清中的表达差异。结果在PCV患者血清中Eotaxin平均浓度为(48.90±24.76)pg/m L,高于对照组(37.49±14.39)pg/m L,差异具有统计学意义(P<0.05)。其他几种趋化因子的表达无明显差异(P>0.05)。结论 Eotaxin在PCV血清中表达明显增高,提示Eotaxin可能在PCV的发生和发展中起重要作用。Objective This study was aimed to evaluate the expression of six chemokines in serum of polypoidal choroidal vasculopathy and to provide evidence for further exploring the pathogenesis of PCV. Methods The serum samples of 30 patients with PCV were collected and 35 cataract patients without fundus disease were served as control. The expressions of Eotaxin,GRO-alpha,IL-8,IP-10,MCP-1 and RANTES were measured by multiplex immunoassay,and the differences between the two groups were analyzed. Results The average concentration of Eotaxin in patients with PCV was（ 48. 90 ± 24. 76） pg/ml,higher than that of the control group（ P〈 0. 05）. The levels of other chemokines revealed no significant differences between the two groups（ P〉 0.05）. Conclusion Eotaxin was highly expressed in patients with PCV,suggesting that it may play an important role in PCV.

关 键 词：息肉状脉络膜血管病变 趋化因子 嗜酸性粒细胞活化趋化因子 多因子检测技术 

分 类 号：R774[医药卫生—眼科]