新型光敏剂在肝癌中的应用  

Application of Novel-photosensitizer in Liver Cancer

作　　者：陈康[1] 冯勇[1] 郑砚文 熊力[1] 文宇[1] 苗雄鹰[1] 

机构地区：[1]中南大学湘雅二医院肝胆外科,湖南长沙410011

出　　处：《激光生物学报》2017年第2期104-108,共5页Acta Laser Biology Sinica

基　　金：国家自然科学基金(81472738;81372628;81402536);科技部创新项目(X8C1Y0K9);湖南省自然科学基金资助项目(12JJ5048)

摘　　要：肝癌晚期,手术切除往往效果不佳,5年生存率低。因此,通过新的辅助治疗方式提高患者生存期是必要的。光动力疗法作为晚期肝癌的姑息性治疗方法,光敏剂是光动力疗法中至关重要的因素。几十年来,光敏剂经过不断发展,如今已出现了许多新型光敏剂,它们具有靶向性高、脂溶性强、生物利用度高等特点,随着肝脏肿瘤多学科合作模式的逐渐开展,新型光敏剂及光动力疗法也将在其中扮演重要的角色。Advanced liver cancer creat a result of poor surgical resection and a low 5-year survival rate. Therefore, it is imperative to prolong the survival time of the patients who suffer from liver cancer by the new adjunctive therapy. Photo-dynamic therapy （PDT） serves as the palliative treatment for the malignant tumor of liver in late stage, and the photo-sensitizer plays a crucial role in PDT. The photosensitizer has been successively developed in decades and new photosen-sitizer has been synthesized today, which characterizes high targeting, strong lipid solubility, high bioavailability etc. Novel-photosensitizer and PDT will play important roles in the development of multi-disciplinary cooperation in the thera-py for liver tumor.

关 键 词：光动力疗法 新型光敏剂 纳米光敏剂 肝癌 

分 类 号：R735.7[医药卫生—肿瘤]