吸烟对慢性牙周炎患者龈沟液中HGF表达水平的影响  

The effect of smoking on HGF expression of in gingival sulcus fluid in the patients with chornic periodontitis before and after the periodontal basic treatment

作　　者：柳锋[1] 张行涛[1] 肖玥[1] 胡丽曼[1] 王敬[1] 苏莎[1] 刘冲[1] 殷尧天[1] 胡玮[2] 刘汉忠[3] 

机构地区：[1]湖北省孝感市中心医院口腔科,湖北孝感432000 [2]湖北省孝感市中心医院信息科,湖北孝感432000 [3]湖北省孝感市中心医院病理科,湖北孝感432000

出　　处：《牙体牙髓牙周病学杂志》2017年第6期334-337,共4页Chinese Journal of Conservative Dentistry

基　　金：湖北省卫计委科研课题项目(WJ2015MB237)

摘　　要：目的:探讨吸烟对慢性牙周炎患者牙周基础治疗前后龈沟液(GCF)中肝细胞生长因子(HGF)表达水平的影响。方法:选择慢性牙周炎患者60例,其中吸烟与非吸烟患者各30例,于牙周治疗前及治疗4周后检查记录菌斑指数(PLI)、探诊深度(PD)、龈沟出血指数(SBI)、附着丧失(AL),并采集GCF样本,采用酶联免疫吸附法(ELISA)检测GCF中的HGF浓度及总量。结果:治疗前吸烟组PLI、HGF的浓度及总量与非吸烟组相比具有统计学差异(P<0.05)外,其他指标2组均无显著差异(P>0.05)。牙周治疗4周后,非吸烟组的PLI、SBI、PD、AL指标均明显低于吸烟组(P<0.05);两组患者牙周临床指标、HGF的总量和浓度均较治疗前明显降低(P<0.05),且非吸烟组HGF浓度(2.69±0.58)ng/m L明显低于吸烟组(3.04±0.63)ng/m L(P<0.05)。结论:吸烟与慢性牙周炎患者HGF水平具有一定相关性。AIM： To study the influence of smoking on HGF expression in gingival sulcus fluid（GCF） in the patients with chronic periodontitis befeor and after basic treatment.METHODS： 60 patients with chronic periodontitis, 30 smoking（group S） and 30 non-smoking（group NS）, were included.Before and 4 weeks after basic treatment, tooth plaque index （PLI）, exploration probing depth （PD）, gingival sulcus bleeding index （SBI） and attachment loss （AL） were examined.HGF level in GCF were measured by ELISA.RESULTS： Befeor treatment PLI and HGF level in group S were higher than those in group NS（P〈0.05）.After treatment, PLI, SBI, PD and AL in both groups were decreased, in group NS were lower than those in group S（P〈0.05）.The HGF concentration in both groups were reduced after treatment（P〈0.05）, in group NS was lower than in group S.CONCLUSION： HGF level is related with smoking in patients with chonronic peridontitis.

关 键 词：吸烟 慢性牙周炎 龈沟液 肝细胞生长因子(HGF) 

分 类 号：R781.4[医药卫生—口腔医学]