依达拉奉早期治疗老年高血压性脑出血对血清炎性因子及氧化应激指标的影响  

The effects of edaravone on serum inflammatory factors and oxidative stress in elderly patients with hypertensive intracerebral hemorrhage

作　　者：钟璐[1] 田松琴[1] 张义[1] 罗亨勤[1] 

机构地区：[1]中国人民解放军第五十九医院神经内科,云南开远661699

出　　处：《川北医学院学报》2017年第3期399-402,共4页Journal of North Sichuan Medical College

摘　　要：目的:探讨依达拉奉早期治疗老年高血压性脑出血(hypertensive intracerebral hemorrhage,HICH)对血清炎性因子及氧化应激指标的影响。方法:选择100例老年HICH患者,按入组序列号奇偶数分为观察组与对照组,每组50例。对照组给予控制血压、降颅内压、止血、脱水、神经营养药物等脑出血常规治疗;观察组在脑出血常规治疗基础上,给予依达拉奉治疗。比较两组治疗前、治疗第3天、7天及14天血清炎症因子hs-CRP、IL-6、TNF-α及氧化应激指标NO、MAD、SOD水平。结果:(1)两组治疗第3天血清hs-CRP、IL-6及TNF-α水平均高于治疗前时,治疗第7天、第14天下降,且低于第3天,第14天低于治疗前,各时间点差异均有统计学意义(均P<0.05);观察组治疗第3天、第7天、第14天时血清hs-CRP、IL-6及TNF-α水平均低于对照组同时间点,差异均有统计学意义(均P<0.05);(2)两组治疗第3天血清NO、MAD水平均高于治疗前时,治疗第7天、第14天下降,且低于第3天,第14天低于治疗前;治疗第3天、第7天、第14天的SOD水平均高于治疗前,且第3天<第7天<第14天,各时间点差异均有统计学意义(均P<0.05);观察组治疗第3天、第7天、第14天时血清NO、MAD水平均低于对照组,SOD水平高于对照组同时间点,差异均有显著统计学意义(均P<0.05)。结论:依达拉奉早期治疗老年HICH可有效减轻机体炎症反应,抑制氧化应激损伤。Objective：To explore the effects of edaravone on serum inflammatory factors and oxidative stress in elderly patients with hypertensive intracerebral hemorrhage（HICH）. Methods： I00 elderly patients with HICH were selected whose were divided into the observation group and the control group according to the group into the group serial number odd even, and each group of 50 cases. The control group was given conventional treatment, such as controlling blood pressure,lowering intracranial pressure,hemostasis,dehy- dration,neurotrophic drugs and so on,and the observation group was given edaravone treatment on the basis of conventional treatment of cerebral hemorrhage. These data were compared that the serum levels of inflammatory factors hs-CRP, IL-6,TNF-a, and oxidative stress indicators NO, MAD and SOD levels in the two groups before treatment and treatment of 3d ,7d, 14d. Results： The serum hs-CRP, IL-6 and TNF-a levels in the treatment of 3d were higher than the before treatment with the two groups, the treatment with 7d and 14d were lower than the 3d, and 14d was lower than before treatment. The differences were statistically significant at each time point （all P 〈 0. 05 ）. The hs-CRP, IL-6 and TNF-a levels of the observation group at 3d ,7d and 14d were lower than the control group at the same time point. The difference was statistically significant （P 〈 0.05）. The serum NO and MAD levels in the treatment of 3d were higher than the before treatment with the two groups,the treatment with 7d and 14d were lower than the 3d,and 14d was lower than before treat- ment. The SOD level of treatment 3d,7d and 14d were higher than the before treatment and the 3d 〈 7d 〈 14d with the two groups. The differences were statistically significant at each time point （ all P 〈 0.05）. The serum NO and MAD levels of the observation group at 3d,7d and 14d were lower than the control group and the SOD level was higher than the control group at the same time point. The differences were statistically signific

关 键 词：依达拉奉 高血压性脑出血 炎性因子 氧化应激 

分 类 号：R743.34[医药卫生—神经病学与精神病学]