补体C3、C4水平对尼莫地平治疗脑梗死血管性认知功能障碍患者疗效的影响  

Effects of C3 and C4 Levels on the Clinical Efficacy of Nimodipine in the Treatment of Vascular Cognitive Impairment in Patients with Cerebral Infarction

作　　者：韦彬[1] 黄进瑜[1] 卢非[1] 唐利艳[1] 

机构地区：[1]广西科技大学第一附属医院神经内科,柳州545002

出　　处：《医学研究杂志》2017年第6期164-167,共4页Journal of Medical Research

摘　　要：目的探讨补体C3、C4水平对尼莫地平治疗脑梗死血管性认知功能障碍患者疗效的影响。方法选取2013年3月~2015年10月广西科技大学第一附属医院神经内科诊治的74例脑梗死血管性认知功能障碍患者为研究对象,分别予以口服尼莫地平片,每日3次,每次45mg,治疗持续12周,先采用简易智能精神状态检查量表(mini-mental state examination,MMSE)和中文版蒙特利尔量表(Montreal cognitive assessment,MoCA)检测患者的认知功能水平,随后运用免疫散射比浊法测定血清补体C3和C4水平的改变。所有患者补体C3和C4测定值分别为1.69±0.18g/L和0.37±0.07g/L;依据补体C3和C4正常临界值将患者分为高补体C3组、低补体C3组、高补体C4组和低补体C4组。结果低补体C3组患者的时间定向力、空间定向力、延迟回忆力、计算力、MoCA量表评分均明显高于高补体C3组(P<0.05);而高补体C4组患者空间定向力、计算力和MoCA量表评分均明显低于低补体C4组,差异有统计学意义(P<0.05);两组间其余各项指标比较差异均无统计学意义(P>0.05)。结论脑梗死血管性认知功能障碍患者补体C3和C4水平越低,其利用尼莫地平治疗的疗效越良好。Objective To investigate the effects of C3 and C4 levels on the clinical efficacy of nimodipine in the treatment of vascu- lar cognitive impairment in patients with cerebral infarction. Methods The 74 cases of cerebral infarction with vascular cognitive impair- ment in the Department of Neurology, First Affiliated Hospital of Guangxi University of Science and Technology were selected in this study from March 2013 to October 2015. Patients were treated orally with nimodipine tablets, three times one day, 45rag each time, and this treatment lasted for 12 weeks. The Mini - mental state examination （MMSE） and Montreal Cognitive Assessment （MoCA） scale were used to evaluate the cognitive function, and then, the levels of serum complement C3 and C4 were measured by immune scatter turbidity method. The levels of complement C3 and C4 were 1.69 ± 0.18g/L and 0.37 ±0.07g/L in all patients, and the patients were then divid- ed into high complement group C3, low complement C3 group, high C4 group and low C4 group according to the normal critical value of C3 and C4. Results Time orientation, spatial orientation, delayed recall, and MoCA scores in the low complement C3 group were signif- icantly higher than those in the high complement C3 group （P 〈 0.05 ）. The spatial orientation, computational power and MoCA scale score of high complement C4 group were significantly lower than those of the low complement C4 group （ P 〈 0.05）. No statistically signif- icant difference was observed on the other indicators between the two groups （ P 〉 0.05）. Conclusion The curative effect of nimodipine on the treatment of vascular cognitive impairment in patients with cerebral infarction is deemed effective when the level of complement C3 and C4 reduced.

关 键 词：补体 尼莫地平 脑梗死 认知障碍 

分 类 号：R741.05[医药卫生—神经病学与精神病学]