平阳霉素碘油乳剂治疗肝血管瘤的疗效及安全性评价  

The Efficacy and Safety Evaluation of PLE in the Treatment of Hepatic Hemangioma

作　　者：林洋 杨巧丽 罗斌 杨波 李玉伟 Lin Yang Yang Qiaoli Luo Bin Yang Bo Li Yuwei(Intervention Ward, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China Radiology Department, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China)

机构地区：[1]西南医科大学附属医院介入病房,泸州646000 [2]西南医科大学附属医院放射科,泸州646000

出　　处：《成都医学院学报》2016年第6期702-705,共4页Journal of Chengdu Medical College

摘　　要：目的探讨平阳霉素碘油乳剂(pingyangmyclin lipiodol emulsion,PLE)栓塞治疗肝血管瘤的疗效及安全性,为临床应用提供参考。方法 32例肝血管瘤患者栓塞治疗后,观察其术后并发症;术后1周评估手术对患者血常规及肝功能的影响;术后12个月,了解患者入院相关症状的改善情况,并行增强CT检查了解血管瘤变化。结果 32例患者术后11例出现不同程度发热、疼痛、恶心、食欲不振症状,给予解热镇痛及护胃等处理后均好转。术后1周复查血常规及肝功能,和术前比较,差异无统计学意义(P>0.05)。术后12个月行增强CT检查:CR10例,PR 18例,SD 3例,PD 1例,血管瘤直径为(4.109±2.844)cm,和术前[(8.056±2.484)cm]比较,差异有统计学意义(t=5.912,P<0.05)。27例有肝区隐痛、上腹饱胀不适等入院相关症状的患者中23例(CR 5例+PR18例)症状改善,余4例(SD 3例+PD 1例)症状无明显变化。结论 PLE栓塞治疗肝血管瘤安全有效。Objective To investigate the efficacy and safety of Pingyangmyclin Lipiodol Emulsion （PLE） in the treatment of hepatic hemangioma and provide references for clinical application. Methods The postoperative complications of the 32 cases with hepatic hemangioma were observed after embolotherapy. The blood routine examination results and liver function of those patients were evaluated after 1 week of the operation. The improvement of the symptoms associated with hepatic hemangioma were investigated and the changes of hepatic hemangioma were evaluated by the enhanced CT examination. Results There were different degrees of fever, pain, nausea and loss of appetite in 11 cases, and the conditions were improved by means of antipyretic analgesic and stomach protection. There were no significant differences in the blood routine examination results and liver function between before the operation and after 1 week of the operation （P〉0.05）. The results of enhanced CT examination showed that there were 10 CR cases, 18 PR cases, 3 SD cases, and 1 PD case, and the postoperative diameter of the hepatic hemangioma was （4. 109±2. 844） cm and it was significantly different from the preoperative diameter which was （8. 056±2. 484） cm （t=5. 912, P〈0.05）. Among the 27 patients with the symptoms such as dull pain in liver and abdominal discomfort, etc. the symptoms of 23 cases （5 CR cases and 18 PR cases） were improved, and those of the other 4 cases （3 SD cases and 1 PD case） were not improved significantly. Conclusion PLE is safe and effective in the embolotherapy of hepatic hemangioma, so it is worth clinical promotion.

关 键 词：介入性 血管瘤 治疗效果 

分 类 号：R732.2[医药卫生—肿瘤]