青年与老年尸体颈总动脉流变特性对比分析  

Rheological properties of the common carotid artery in young versus aged cadavers

作　　者：许东辉[1] 黄淑华[2] 李新颖[3] 李东原[1] Xu Dong-hui Huang Shu-hua Li Xin-ying Li Dong-yuan(Department of Neurosurgery 3Department of Ultrasound, China-Japan Union Hospital, Jilin University, Changchun 130031, Jilin Province, Chin 2Department of Ophthalmology, Jilin Provincial People＇s Hospital, Changchun 130026, Jilin Province, China)

机构地区：[1]吉林大学中日联谊医院神经外科,吉林省长春市130031 [2]吉林省人民医院眼科,吉林省长春市130026 [3]吉林大学中日联谊医院超声科,吉林省长春市130031

出　　处：《中国组织工程研究》2017年第16期2527-2533,共7页Chinese Journal of Tissue Engineering Research

基　　金：吉林省科技发展计划资助项目(20110492)~~

摘　　要：背景:研究发现,随着年龄增加和血压的增高,血管基质退化使弹力层断裂和破碎,使钙质和胶原沉积,大动脉和主动脉扩张导致动脉僵硬度的提高。目的:对比分析青年颈总动脉组和老年颈总动脉的流变特性,为研究颈总动脉粥样硬化的发病机制提供流变特性基础。方法:随机取青年尸体和老年尸体颈总动脉组各10个试样,分别进行应力松弛、蠕变实验,随机取青年和老年颈总动脉组1个试样进行组织形态观察。结果与结论:(1)青年颈总动脉组试样7 200 s应力下降量显著大于老年颈总动脉组(P<0.05);(2)青年颈总动脉组试7 200 s应变上升量显著大于老年颈总动脉组(P<0.05);(3)扫描电镜观察发现,老年颈总动脉组可见脂质斑块,泡沫细胞积聚,内弹力层和中弹力板发生变性、断裂和崩解,内膜和中膜可见大量的斑快和炎细胞浸润,组织形态具有动脉粥样硬化的特征;青年颈总动脉组未见粥样硬化斑块;(4)结果说明,随着年龄的增加,老年颈总动脉弹性纤维和胶原纤维的排列关系被打乱,其应力松弛、蠕变特性发生了改变。BACKGROUND： With age and blood pressure increasing, the damaged elastic membrane induced by degenerative vascular matrix results in calcium and collagen deposition, and finally expanded large arteries and aortas are easy to cause arteriosclerosis. OBJECTIVE： To compare the rheological properties of the common carotid artery in the youth and elderly, thus providing a basis for the study on the pathogenesis of atherosclerosis of the common carotid artery. METHODS： Common carotid arteries were respectively removed from the young and elderly cadavers. Ten samples from each group were randomly selected, and subjected to stress relaxation and creep tests. Meanwhile, one sample from each group was selected for histological observation. RESULTS AND CONCLUSION： The stress at 7200 s in the young group was significantly decreased compared with the elderly group （P 〈 0.05）. The strain at 7200 s in the young group was significantly increased compared with the elderly group （P 〈 0.05）. Scanning electron microscope observed that in the elderly group, there were lipid plaques and foam cell accumulation; the internal elastic lamina and middle elastic plate presented with degeneration, rupture and disintegration; and there were abundant plaques and inflammatory cells in the intimal and media, which characterized as atherosclerosis. While no lipid plaques were found in the young group. These results indicate that the elastic fibers and collagen fibers in the common carotid artery arrange in disorder as age increases, and the rheological properties are also changed.

关 键 词：颈总动脉 应力 物理 流变学 组织工程 组织构建 青年 老年 应力松弛 蠕变 流变特性 对比分析 

分 类 号：R318[医药卫生—生物医学工程]