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作 者:温子海 吕巧云 李晓华 Wen Zi-hai Lv Qiao-yun Li Xiao-hua(Third Department of Surgery, Fengnan District Hospital, Tangshan Workers Hospital Group, Tangshan 063300, Hebei Province, Chin)
机构地区:[1]唐山市工人医院集团丰南区医院外三科,河北省唐山市063300
出 处:《中国组织工程研究》2017年第17期2741-2745,共5页Chinese Journal of Tissue Engineering Research
摘 要:背景:研究表明,OCT4、SOX2、HIWI等在肿瘤组织中有表达。目的:分析干细胞转录因子SOX2、OCT4在食管鳞癌中的表达变化及与患者临床特征、预后的关系。方法:采用免疫组织化学SP法检测77例手术后经病理学证实为食管鳞癌患者的手术标本(食管癌组)和40例癌旁组织标本(癌旁组织)中SOX2、Oct4蛋白的表达水平,并分析其与患者临床特征、预后的关系。结果与结论:(1)食管癌组织中的SOX2蛋白、Oct4蛋白阳性表达率均显著的高于癌旁组织(P<0.05);(2)食管癌组织中的SOX2蛋白、Oct4蛋白在低分化、淋巴结转移患者中呈显著的高表达(P<0.05);(3)食管癌组织中的SOX2蛋白阳性表达患者的3年随访中位生存期24个月,显著低于阴性患者的30个月;Oct4蛋白阳性表达患者的中位生存时间21个月显著低于阴性患者33个月;(4)结果提示,SOX2、Oct4蛋白在食管癌组织中高表达,并且与患者的分化程度、转移及预后有关。BACKGROUND: Studies have shown that OCT4, SOX2 and HIWI can express in tumor tissues. OBJECTIVE: To investigate the relationship between the expression of stem cell transcription factors SOX2 and OCT4 in esophageal squamous cell carcinoma and their clinical characteristics and prognosis. METHODS: Expression levels of SOX2 and Oct4 were detected using immunohistochemical SP method in 77 cases of esophageal squamous cell carcinoma and 40 cases of adjacent cancer tissues confirmed by pathological examination, and then the their relationship with prognosis and clinical characteristics of the patients was analyzed. RESULTS AND CONCLUSION: Significantly higher levels of SOX2 and Oct4 were found in the esophageal cancer tissues than the adjacent cancer tissues (P 〈 0.05). SOX2 and Oct4 were highly expressed in the esophageal cancer tissues isolated from poorly differentiated, lymph node metastasis patients (P 〈 0.05). During the 2-year follow-up, the median survival of patients positive for SOX2 and Oct4 was only 24 and 21 months, respectively, which was significantly lower than that of negative patients (30 and 33 months, respectively). These findings indicate that the highly expressed SOX2 and Oct4 in esophageal cancer tissues are associated with the differentiation, metastasis and prognosis of the patients with esophageal squamous cell carcinoma.
关 键 词:干细胞 肿瘤干细胞 食管鳞癌 Sry相关HMG盒2 八聚体结合转录因子4 临床特征 预后
分 类 号:R394.2[医药卫生—医学遗传学]
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