IL-6与P-选择素在非小细胞肺癌中的表达及临床意义  

Expression and the significance of P-slectin and IL-6 in non-small lung cancer

作　　者：尹超[1] 余红岚[2] 杨梅[3] 费樱[4] 喻云平 

机构地区：[1]贵州医科大学医学检验学院,贵州贵阳550004 [2]贵阳市第一人民医院检验科,贵州贵阳550002 [3]贵阳中医学院第二附属医院检验科,贵州贵阳550001 [4]贵州医科大学附属医院微生物免疫科,贵州贵阳550004

出　　处：《贵州医药》2017年第6期578-580,共3页Guizhou Medical Journal

基　　金：贵州省科技厅联合基金课题[黔科合中药字(2010)LKZ7008号]

摘　　要：目的探讨IL-6与P-选择素在非小细胞肺癌中的表达及其临床意义。方法 ELISA和免疫组化检测50例术前、术后3周内非小细胞肺癌患者外周血中IL-6与P-选择素的水平以及术后癌组织中和癌旁组织中的表达。结果 (1)肺组织中的IL-6表达明显高于癌旁组织(P<0.05)与吸烟指数和病情严重程度有关(P<0.05),与肿瘤大小和组织分型无关(P>0.05),免疫组化阳性表达者血清IL-6水平明显高于阴性患者;术后外周血IL-6与P-选择素的浓度明显低于术前,差异具有统计学意义(P<0.05)。(2)肺组织中的P-选择素表达明显高于癌旁组织(P<0.05),只与病理分期和组织类型有关(P<0.05),免疫组化阳性表达者血清P-选择素水平高于阴性患者,但差异无统计学意义(P>0.05)。(3)非小细胞肺癌患者外周血中IL-6与P-选择素的水平没有明显的相关性(r=0.424,P>0.05)。结论非小细胞肺癌患者体内存在的IL-6,P-选择素的高表达与肿瘤的发生发展有关;血清中升高的IL-6可能来源于肺癌肿瘤组织中IL-6的高表达。Objective To study the expression and the significance of P-slectin and IL-6 in non-small lung cancer patients.Methods ELISA was adopted to detect the levels of P-selectin,IL-6 before operation and within three weeks in 50 patients with non-small cell lung cancer.Immunohistochemistry was adopted to detect the expression of P-slectin and IL-6 in cancer tissue and paracancerous tissue of 50 non-small lung cancer patients.Results The expression of IL-6 in the lung tissue was significantly higher than adjacent tissues （P〈0.05）,which were found to be associated with severity of the disease and smoking index,independent of the type of pathology and size （P〉0.05）.The level of serum IL-6′s Immunohistochemical expression positive in patients was significantly higher than that with negative.Postoperative peripheral blood IL-6 and p-selectin was significantly lower than before the operation,and there were statistical significantly differences （P〈0.05）. The expression of P-slectin in the lung tissue was significantly higher than adjacent tissues （P〈0.05）,which were found to be associated with pathological staging and organization type （P〈0.05）.The level of serum P-slectin′s Immunohistochemical expression positive in patients was significantly higher than that with negative,but there were no statistical significantly differences （P〉0.05）. The levels of IL-6 were no obviously associated with that of p-selectin in the peripheral blood of patients with non-small cell lung cancer （r=0.424,P〉0.05）.Conclusion The high expression of P-electin and IL-6 in patients with non-small cell lung cancer was associated with tumor development.Preoperative elevated serum IL-6 may be derived from tumor tissues in most patients with NSCLC.

关 键 词：IL-6 P-选择素 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]