妊娠期肝内胆汁淤积症患者甲状腺激素早期检测的临床价值分析  

Clinical Value of Early Detection of Thyroid Hormone in Patients With Intrahepatic Cholestasis of Pregnancy

作　　者：林琳[1] 刘照贞[1] 黄丽萍[1] 刘达宾[1] 

机构地区：[1]福建医科大学教学医院/福建省妇幼保健院妇产科,福建福州350001

出　　处：《中国卫生标准管理》2017年第13期122-124,共3页China Health Standard Management

摘　　要：目的探讨早期甲状腺激素检测在妊娠期肝内胆汁淤积症(Intrahepatic Cholestasis of Pregnancy,ICP)患者中的临床价值。方法回顾性分析2014年7月1日—2017年2月28日福建省妇幼保健院妇产科收治的妊娠期肝内胆汁淤积症患者62例(研究组),同期随机选择30例健康孕妇(对照组),对两组孕妇临床资料进行统计比较,并分析甲状腺激素早期检测在ICP患者中的临床价值。结果研究组TBA和TSH水平均高于对照组(P<0.05);而研究组FT_3与FT_4水平均低于对照组(P<0.05);对照组和研究组TBA异常率分别为0%和96.77%;对照组和研究组FT_3异常率分别为6.67%和91.94%;对照组和研究组FT_4异常率分别为13.33%和90.32%;对照组和研究组TSH异常率分别为6.67%和91.94%;研究组TBA、FT_3、FT_4、TSH异常率均高于对照组(P<0.05);FT_3、FT_4、TSH检测在ICP患者诊断中其敏感性与特异性均较高,可以作为ICP早期诊断的辅助检测指标。结论甲状腺激素检测在妊娠期肝内胆汁淤积症患者中具有重要的临床价值,可以作为早期诊断的辅助性指标。Objective To investigate the clinical value of early detection of thyroid hormone in patients with intrahepatic cholestasis of pregnancy （Intrahepatic Cholestasis of Pregnancy, ICP）. Methods A retrospective analysis from July 1, 2014 to February 28, 2017 in obstetrics and gynecology department in Fujian Provincial Maternity and Child Care Center intrahepatic cholestasis of pregnancy in 62 patients （study Group）, randomly selected 30 healthy pregnant women （control group）. The clinical data of two pregnant women were compared, and the clinical value of early detection of thyroid hormone in patients with ICP was analyzed. Results TBA and TSH levels of the study group were higher than the control group （P 〈 0.05）; while the FT3 and FT4 levels of the study group were lower than those of the control group （P 〈 0.05）; the abnormal rate of TBA were 0% （the control group） and 96.77%（the study group）; the abnormal rate of FT3 were 6.67% （the control group）and 91.94%（the study group）; the abnormal rate of FT4 were 13.33%（the control group） and 90.32%（the study group）; the abnormal rate of TSH were 6.67%（the control group） and 91.94%（the study group）; the abnormal rates ofTBA, FT3, FT4, TSH of the study group were all higher than those of the control group （P 〈 0.05）; detection of FT3, FT4 and TSH in patients with ICP has high sensitivity and specificity, and it can be used as auxiliary indexes for early diagnosis of ICE Conclusion Thyroid hormone test has important clinical value in patients with intrahepatic cholestasis of pregnancy, and can be used as an auxiliary indicator for early diagnosis.

关 键 词：ICP FT4 FT3 TSH 临床价值 

分 类 号：R714.25[医药卫生—妇产科学]