齐墩果酸对氟伐他汀在大鼠体内药动学的影响  

Effect of Oleanolic Acid on the Pharmacokinetics of Fluvastatin in Rats

作　　者：杨茗钫[1] 徐文炜[2] 程晓华[1] YANG Mingfang XU Wenwei CHENG Xiaohua(The First Affiliated Hospital of Nanchang University, Nanchang 330006, China Institute of Clinical Pharmacology of Nanchang University, Nanchang 330006, China)

机构地区：[1]南昌大学第一附属医院,南昌330006 [2]南昌大学临床药理研究所,南昌330006

出　　处：《中国现代应用药学》2017年第6期811-814,共4页Chinese Journal of Modern Applied Pharmacy

基　　金："重大新药创制"国家科技重大专项(2011ZX09302-007-03);江西省青年科学基金计划项目(20142BAB215019);江西省卫生计生委科技计划项目(20175136)

摘　　要：目的探讨齐墩果酸对氟伐他汀在大鼠体内的药动学影响。方法将16只健康大鼠随机分为单药组(5.0 mg·kg^(-1)氟伐他汀)和联合用药组(5.0 mg·kg^(-1)氟伐他汀+60 mg·kg^(-1)齐墩果酸),单药组和联合用药组分别灌胃空白溶剂和齐墩果酸5 d,每天1次,第6天2组均给予氟伐他汀灌胃。给药后不同时间点采血,LC-MS测定大鼠体内血药浓度,比较2组间主要的药动学参数。结果与单药组比较,联合用药组氟伐他汀主要药动学参数Cmax、AUC0-t显著上升,组间比较差异具有统计学意义(P<0.05)。结论联合应用齐墩果酸可能影响大鼠体内氟伐他汀的药动学特性。OBJECTIVE To explore the effect of oleanolic acid（OA） on the metabolism of fluvastatin in rats. METHODS Sixteen health rats were randomly divided into two groups： the single group（fluvastatin 5.0 mg·kg^（-1）） and the combined group（fluvastatin 5.0 mg·kg^（-1）＋OA 60 mg·kg^（-1））. The single group were administrated with blank solution while the combined group were administrated with the same volume of OA, the administration period of 5 d. At the sixth day, both groups were administrated with fluvastatin, plasma concentrations of fluvastatin were determined by LC-MS. The main pharmacokinetic parameters were calculated and compared. RESULTS The main pharmacokinetic parameters（Cmax, AUC0-t） of the combined group showed increased remarkably compared with the single group. Statistically significant difference was showed between groups（P〈0.05）. CONCLUSION OA can affect the pharmacokinetic parameters of fluvastatin in rats.

关 键 词：氟伐他汀 齐墩果酸 药动学 高效液相色谱质谱联用 

分 类 号：R969.1[医药卫生—药理学]