硫辛酸治疗干性老年黄斑变性临床疗效观察  

Clinical effects observation of oL-lipoic acid treatment in patients with dry age-related macular degeneration

作　　者：孙晓玲[1] 庞栋[2] 王静[3] 孙丽媛[2] 王红[2] 

机构地区：[1]烟台毓璜顶医院,264000 [2]山东大学齐鲁医院,250001 [3]济南市第二人民医院,250001

出　　处：《中国实用眼科杂志》2017年第5期498-501,共4页Chinese Journal of Practical Ophthalmology

摘　　要：目的观察硫辛酸胶囊治疗干性老年黄斑变性（AMD）的疗效。方法回顾性病例系列研究。将山东大学齐鲁医院2014年5月至2015年10月收治的120例干性AMD患者分为2组：治疗组给予硫辛酸治疗，每天一次口服0.2 g；对照组给予维生素C，每天一次口服1.0 g作为安慰剂。于用药前及用药3个月后分别测量超氧化物岐化酶（SOD）值、BCVA、CS、CLVQOL值，比较用药前后患者以上指标的变化。结果与用药前相比，治疗组血清SOD值，中、低频段对比敏感度及CLVQOL评分与用药前比较差异均有统计学意义（P〈0.05），而BCVA及高频段对比敏感度与用药后比较差异没有统计学意义（P〉0.05）；对照组上述观察指标于治疗前后差异没有统计学意义。治疗组CLVQOL评分与低频段的对比敏感度（3 cyc/d）呈正相关（P〈0.05）。结论硫辛酸胶囊能提高AMD患者的抗氧化能力，提高患者的生存质量，对预防AMD的发生和发展有一定的作用。ObjectiveTo observe the effect of sulfur acid capsules of the treatment of age-related macular degeneration.Methods120 patients with dry AMD treated in our hospital from May 2014 to Oct 2015 were divided into 2 groups randomly.60 patients treated with LA 0.2g each time, once a day orally, 60 patients treated with placebo vitamin C 0.05g each time, once a day orally.Before and after the intervention, the SOD value, BCVA,CS and CLVQOL values were measured before and after 3 months. The changes of patients were compared before and after intervention.ResultsCompared with pre intervention, serum SOD, middle-low frequency contrast sensitivity and CLVQOL score before and after the intervention were statistically significant （P 〈0.05）, high frequency contrast sensitivity and visual acuity before and after the intervention was not statistically significant （P 〉0.05） in treated group. CLVQOL scores were positively correlated with contrast sensitivity at low spatial frequency （3 cyc/degree） in LA-treated group.ConclusionLA capsules can improve the antioxidant capacity of dry AMD patients and improve the quality of life of patients. It is important to prevent the occurrence and development of dry AMD.

关 键 词：老年黄斑变性 硫辛酸 SOD CLVQOL BCVA 

分 类 号：R774.5[医药卫生—眼科]