盐酸羟考酮对全麻下行结肠癌根治术患者应激反应的影响  

Influence of Oxycodone Hydrochloride on Stress Response of Patients Underwent General Anesthesia for Colon Cancer Radical Surgery

作　　者：张迪[1] 姜万维[1] 崔家华[1] 王庆辉[1] ZHANG Di JIANG Wan-wei CUI Jia-hua WANG Qing-hui(The Second Dept. of Anesthesia, Zhongshan Hospital Affiliated to Dalian University, Dalian , Liaoning 116001)

机构地区：[1]大连大学附属中山医院麻醉二科,辽宁大连116001

出　　处：《中国肛肠病杂志》2017年第5期13-15,共3页Chinese Journal of Coloproctology

摘　　要：为探讨盐酸羟考酮对全麻下行结肠癌根治术患者应激反应的影响,选择大连大学附属中山医院施行结肠癌根治术治疗的80例患者进行研究,随机分为A、B 2组,每组40例.2组均采用全身静脉麻醉,予以咪达唑仑、舒芬太尼、依托咪酯、苯磺顺阿曲库铵诱导,丙泊酚、瑞芬太尼、苯磺顺阿曲库铵维持,A组麻醉诱导前静脉注射生理盐水5 mL,B组麻醉诱导前静脉注射盐酸羟考酮5 mg（1 mg/mL）.分别于注射试验药品之前（T0）、注药后30 min（T1）、注药后2 h（T2）、手术结束前（T3）、拔除气管导管后即刻（T4）测量2组患者静脉血中肾上腺素（E）和去甲肾上腺素（NE）含量及胃黏膜的pH值,统计术后24 h内胃溃疡发生率.结果显示,2组T0时刻静脉血中E、NE含量及胃黏膜的pH值比较差异均无统计学意义,P〉0.05.B组T1、T2、T3、T4时刻静脉血中E和NE含量均明显低于A组,P〈0.05;B组T1、T2、T3、T4时刻胃黏膜的pH值明显高于A组,P〈0.05.B组术后24 h内胃溃疡发生率明显低于A组,P〈0.05.结果表明,盐酸羟考酮注射液可以有效减轻全麻下行结肠癌根治术患者的应激反应.In order to explore the influence of Oxycodone Hydrochloride on stress response of patients undergoing general anesthesia for colon cancer radical surgery, 80 patients underwent radical resection of colon cancer in Zhongshan hospital affiliated to Dalian university were randomly divided into group A and group B ,40 cases for each.The two groups all received total intravenous anesthesia induced by Midazolam, Sufentanil, Etomidate, Cisatracurium besilate and maintained by Propofol, Remifentanil, Cisatracurium besilate.5 mL of normal saline was injected intravenously before the induction of anesthesia in group A, and 5 mg （1 mg / mL） of Oxycodone Hydrochloride was injected intravenously in group B before induction.The content of Epinephrine （E）, norepinephrine （NE） in venous blood, gastric mucosal pH at T0 （before injection test drugs）, T1 （30 mins after injection）, T2 （2 h after injection）, T3 （before the end of operation） and T4 （the moment of removing endotracheal tube） were measured and the incidence of gastric ulcer within 24 h were counted.As results, there was no significant difference in E, NE content and pH value of gastric mucosa between the two groups at the time of T0（P〉0.05）.The content of E and NE in venous blood at T1, T2, T3 and T4 of group B was significantly lower than that of group A （P〈0.05）.The pH value of gastric mucosa in group B was significantly higher than that in group A （P〈0.05）.The incidence of gastric ulcer within 24 h after operation in group B was significantly lower than that in group A （P〈0.05）.In conclusion, Oxycodone Hydrochloride injection can effectively reduce the stress response of patients underwent colon cancer radical surgery.

关 键 词：结肠癌根治术 盐酸羟考酮 应激反应 胃溃疡 

分 类 号：R735.35[医药卫生—肿瘤]