多学科治疗转移性胰腺癌的预后及影响因素分析  

Analysis on prognosis and influencing factors of multidisciplinary treatment for metastatic pancreatic cancer

作　　者：邓小强[1] 王利娜[1] 孙胜[1] 罗威[1] 罗吉辉[2] 

机构地区：[1]漯河市中心医院普通外一科,河南462000 [2]南方医科大学附属郴州医院肿瘤外科,湖南郴州423000

出　　处：《现代医药卫生》2017年第13期1954-1957,共4页Journal of Modern Medicine & Health

摘　　要：目的探讨多学科治疗转移性胰腺癌的预后及影响因素。方法采用回顾性病例对照研究方法收集2010年1月至2015年7月河南省漯河市中心医院收治的168例转移性胰腺癌患者的临床资料。随访至2016年10月,其中146例患者(86.9%)获得随访。分析转移性胰腺癌多学科治疗的预后及影响因素。结果 146例患者中男89例,女57例;区域转移78例,远处转移68例;多学科治疗57例,单学科治疗68例,放弃治疗21例。125例接受治疗患者中位生存期(MS)、半年及1年生存率分别为6.7个月、54.4%(68/125)、4.8%(6/125);多学科治疗患者的MS、半年及1年生存率明显高于单学科治疗患者,差异均有统计学意义(P<0.05)。年龄、行为状态评分(KPS)、营养风险筛查表(NRS2002)评分、治疗方式、肿瘤转移情况是转移性胰腺癌患者生存率的影响因素,差异均有统计学意义(P<0.05)。结论多学科治疗有助于提高转移性胰腺癌患者的总体生存率,KPS≤80分、NRS2002评分小于或等于3分、单学科治疗、肿瘤远处转移是影响转移性胰腺癌患者总体生存率的危险因素。Objective To investigate the prognosis and influencing factors of multidisciplinary treatment for metastatic pancreatic cancer. Methods The clinical data of 168 patients with metastatic pancreatic cancer in the Luohe Municipal Central Hospital from January 2010 to July 2016 were collected by using the retrospective case control research method. The followed up lasted until October 2016, in which 146 cases （86.9%） obtained follow up. The prognosis and influencing factors of multidisciplinary treatment for metastatic pancreatic cancer were analyzed. Results Among 146 follow up cases, 89 cases were males, 56 cases were females ;78 cases had regional metastasis, 68 cases had distant metastasis;57 cases received the multidisciplinary treatment,68 case received the single-disciplinary treatment and 21 cases gave up the treatment; among 125 cases receiving treatment, the median survival time （MS）, half-year survival rate and 1-year survival rate were 6.7 months, 54.4% （68/125） and 4.8% （6/125） respectively; MS,half-year survival rate and 1-year survival rate in the patients with muhidisciplinary treatment were significantly higher than those in the patients with single-disciplinary treatment, the difference was statistically significant （P〈 0.05 ）. The age, KPS score, NRS2002 score, treatment mode and tumor metastasis situation were the influencing factors of survival rate in the patients with metastasis pancreatic cancer, the difference was statistically significant （P〈0.05）. Conclusion The mul- tidisciplinary therapy is helpful to improve the overall survival rate of the patients with metastatic pancreatic cancer, and KPS score ≤ 80, NRS2002 score ≤ 3, single-disciplinary treatment and distant metastasis are the risk factors affecting the overall survival rate in the patients with metastatic pancreatic cancer.

关 键 词：胰腺肿瘤/治疗 肿瘤转移/治疗 综合疗法 存活率 危险因素 

分 类 号：R735.9[医药卫生—肿瘤]