CEA、NSE及D-二聚体在胃癌患者中的变化及其临床意义  

Changes of Carcinoembryonic Antigen,Neuron Specific Enolase,D-Dimer in Patients with Gastric Cancer and Their Clinical Significance

作　　者：刘文超[1] 陈静伟[2] 孙向华[3] 

机构地区：[1]廊坊市人民医院检验科,北京100043 [2]首都医科大学附属北京朝阳医院检验科,北京100043 [3]廊坊市人民医院感染科,河北廊坊065000

出　　处：《医学综述》2017年第12期2478-2481,共4页Medical Recapitulate

摘　　要：目的探讨癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)及D-二聚体在胃癌患者中的水平变化及临床意义。方法选取2013年1月至2015年6月廊坊市人民医院收治的行手术治疗的胃癌患者73例作为病例组,选取同时期本院收治的60例胃部良性疾病患者作为良性疾病组,健康体检者60例作为对照组。比较3组研究对象的血清CEA、NSE及D-二聚体水平;比较病例组手术前后以及有无复发患者血清CEA、NSE及D-二聚体水平。结果病例组血清CEA、NSE及D-二聚体水平明显高于良性疾病组和对照组[27.80(0.52~76.32)μg/L比1.94(0.23~10.21)μg/L、1.52(0.07~11.06)μg/L,19.40(3.26~78.49)μg/L比8.71(1.02~12.58)μg/L、7.36(0.89~13.24)μg/L,4.19(0.02~5.41)mg/L比0.47(0.03~1.78)mg/L、0.47(0.03~1.78)mg/L](P<0.05);术后4周,患者血清CEA、NSE及D-二聚体水平均明显低于术前[5.87(0.71~26.75)μg/L比27.80(0.52~76.32)μg/L、10.41(2.43~34.21)μg/L比19.40(3.26~78.49)μg/L、0.52(0.02~3.09)mg/L比4.19(0.02~5.41)mg/L](P<0.05);无复发患者血清CEA、NSE及D-二聚体水平明显低于复发患者[19.62(0.80~44.30)μg/L比5.34(0.40~21.40)μg/L、8.05(1.42~30.94)μg/L比12.60(3.12~41.90)μg/L、0.39(0.04~2.09)mg/L比1.77(0.06~4.29)mg/L](P<0.05)。结论胃癌术后复发患者血清CEA、NSE及D-二聚体水平均明显升高,血清CEA、NSE及D-二聚体水平在胃癌手术患者术后近期预后评估中具有一定的临床意义。Objective To investigate the changes of carcinoembryonic antigen（ CEA）,neuron specific enolase（ NSE）,D-dimer in patients with gastric cancer and their clinical significance. Methods A total of 73 cases of gastric cancer in Langfang People＇s Hospital from Jan. 2013 to Jun. 2015 were selected as a case group,60 patients with benign gastric diseases in the hospital during the same period were selected as a benign disease group,60 cases of healthy physical examination were selected as a control group. The serum levels of CEA,NSE and D-dimer of the three groups were compared; the serum levels of CEA,NSE and D-dimer were compared between patients with and without recurrence and metastasis before and after operation. Results The levels of CEA,NSE and D-dimer in the case group were significantly higher than those in the benign disease group and the control group [27. 80（ 0. 52-76. 32） μg/L vs 1. 94（ 0. 23-10. 21） μg/L,1. 52（ 0. 07-11. 06） μg/L; 19. 40（ 3. 26-78. 49） μg/L vs 8. 71（ 1. 02-12. 58） μg/L,7. 36（ 0. 89-13. 24） μg/L; 4. 19（ 0. 02-5. 41） mg/L vs 0. 47（ 0. 03-1. 78） mg/L,0. 47（ 0. 03-1. 78） mg/L]（ P〈0. 05）; 4 weeks after operation,the levels of CEA,NSE and D-dimer in the patients were significantly lower than those before operation[5. 87（ 0. 71-26. 75） μg/L vs 27. 80（ 0. 52-76. 32） μg/L,10. 41（ 2. 43-34. 21） μg/L vs 19. 40（ 3. 26-78. 49） μg/L,0. 52（ 0. 02-3. 09） mg/L vs 4. 19（ 0. 02-5. 41） mg/L]（ P〈0. 05）; the levels of serum CEA,NSE and D-dimer in patients with recurrence and metastasis were significantly higher than those in patients without recurrence and metastasis[19. 62（ 0. 80-44. 30） μg/L vs 5. 34（ 0. 40-21. 40） μg/L,12. 60（ 3. 12-41. 90） μg/L vs 8. 05（ 1. 42-30. 94） μg/L,1. 77（ 0. 06-4. 29） mg/L vs 0. 39（ 0. 04-2. 09） mg/L]（ P〈0. 05）. Conclusion Serum CEA,NSE,D-dimer levels increase obviously in patients with gastric cancer,which have some clinical significance in the short-term pro

关 键 词：胃癌 手术 癌胚抗原 神经元特异性烯醇化酶 D-二聚体 

分 类 号：R735.7[医药卫生—肿瘤]