小檗碱治疗阿尔茨海默病研究进展  

Research progress of berberine in treatment of Alzheimer's disease

作　　者：张海静[1,2,3] 赵春晖[1,2,3] 张文生[1,2,3] 

机构地区：[1]北京师范大学中药资源保护与利用北京市重点实验室,博士生100088 [2]教育部天然药物工程研究中心 [3]北京师范大学资源学院

出　　处：《环球中医药》2017年第6期763-767,共5页Global Traditional Chinese Medicine

基　　金：国家自然科学基金(81274118);科技部"重大新药创制"科技重大专项(2012ZX09103-201);中央高校基本科研业务费(2015KJJCA05)

摘　　要：阿尔茨海默病(Alzhermer’disease,AD)是一种以学习、记忆和认知功能障碍为主要表现的中枢神经系统退行性疾病。AD作为一种异质性的疾病,其致病机理复杂。小檗碱是一种常见的异喹啉类季铵生物碱,作为一种多靶点作用的药物对AD的病理具有一定的改善作用。包括改善认知能力、减少β淀粉样蛋白(β-amyloid,Aβ)产生、抑制Tau蛋白的过度磷酸化、抗炎、抗氧化、调节中枢神经递质代谢等。本文总结近年来小檗碱治疗AD的有关研究成果,以期为小檗碱防治AD提供借鉴。Alzheimer＇s disease is a neurodegenerative disease of the central nervous system characterized by learning,memory and cognition deficit. AD is a heterogeneous disease,the pathogenesis is complex. Berberine is a common isoquinoline alkaloid,and as a multi-target therapeutic drug,it has the effect of improvement on AD. The functions of berberine include improving cognitive functioning,reducing Aβ level,reducing hyperphosphorylated Tau protein level,,anti-inflammatory,anti-oxidative stress,regulation of the neurotransmitter metabolism and so on. The recent research achievements of berberine in the treatment of AD are summarized in order to provide reference for the prevention and treatment of berberine in AD.

关 键 词：小檗碱 阿尔茨海默病 Β-淀粉样蛋白 神经保护 糖脂代谢 

分 类 号：R749.16[医药卫生—神经病学与精神病学]