≤pT_2N_0M_0膀胱癌根治术后近期复发的影响因素分析  

Influencing factors and prognosis of short-term relapse after radical cystectomy of primary bladder cancer(≤pT_2N_0M_0)

作　　者：陈可新[1] 郝晓东[1] 薄志强[1] 刘豫[1] 杜娥[1] 张志宏[1] CHEN Ke-xin HAO Xiao-dong BO Zhi-qiang LIU Yu DU E ZHANG Zhi-hong(Department of Urology,The Second Hospital, Tianjin Medical University, Tianjin Institute of Urology,Tianjin 300211,China)

机构地区：[1]天津医科大学第二医院泌尿外科天津市泌尿外科研究所,天津300211

出　　处：《天津医科大学学报》2017年第4期357-360,共4页Journal of Tianjin Medical University

基　　金：国家自然科学基金资助项目(81400686)

摘　　要：目的:探讨膀胱癌(≤pT_2N_0M_0)根治术(RC)后患者肿瘤近期复发的影响因素。方法:回顾性分析173例行RC患者的临床资料,将RC术后患者分为两组:≤6月复发为近期复发,>6月为非近期复发。分析肿瘤部位、肿瘤单发或多发、肿瘤直径、肿瘤分期、分级、切断尿道的方式、术中输血等因素与术后肿瘤近期复发的关系。结果:173例患者中63例(36.4%)出现肿瘤复发,其中近期复发19例(10.9%),非近期复发44例(25.4%)。性别、肿瘤数量、离断尿道方式、术中淋巴清扫术、后尿道肿瘤侵犯为近期复发的影响因素(χ~2=4.02、4.73、7.15、4.47、5.42,P<0.05),其中性别、离断尿道方式、肿瘤侵犯后尿道为近期肿瘤复发的独立危险因素(RR=0.124、7.154、5.415,P<0.05)。结论:性别、离断尿道方式、肿瘤侵犯后尿道为RC术后近期复发的独立危险因素。Objective：To investigate the influencing factors and prognosis of short-term recurrence after radical cystectormy （RC） of primary bladder cancer（≤pT2N0M0）. Methods： Clinical data of 173 patients who received radical cystectormy were analyzed. Some patients with early clinical pathological diagnosis, had no lymph node disease （≤pT2N0M0）. Tumor recurrence occurred within 6 months after operation was defined as short-term recurrence. Relationship between postoperative tumor recurrence and the tumor site, tumor number, tumor diameter, tumor staging, grading, the way of mutilating urethra, intraoperative blood transfusion and so on were analyzed. Results： In 173 patients, 63 cases （36.4%） were found tumor recurrence, including 19 cases （10.9%） with in short-term recurrence and non short-term recurrence in 44 cases （25.4%）. Sex, tumor number, mutilating urethra without occlusion, lymph node dissection, posterior urethra invasion were influencing factors for short-term recurrence （χ^2=4.02,4.73,7.15,4.47,5.42,P〈0.05=, sex, posterior urethra invasion, mutilating urethra without occlusion as independent risk factors for recent tumor recurrence （RR=0.124、7.154、5.415,P〈0.05. Conclusion： Sex, the way of mutilating urethra, and the tumor invasion of the urethra are independent risk factors for short-term tumor recurrence. There is a significant difference in the survival rates between patients with short-term and non-short-term tumor recurrence.

关 键 词：膀胱癌 膀胱癌根治术 近期复发 危险因素 

分 类 号：R737.14[医药卫生—肿瘤]