氟西汀对脑卒中后抑郁患者海马磁共振氢质子波谱影响的研究  

Effect of fluoxetine on hydrogen proton magnetic resonance spectroscopy of hippocampus in patients with poststroke depression

作　　者：郭志勇[1] 谭西英[1] 刘丽娇[1] 王宇[1] 任玉红[1] 徐祥辉[1] 李智花 张东卫[2] 

机构地区：[1]新乡市第一人民医院神经内一科,河南新乡453000 [2]河南省精神病医院,河南新乡453000

出　　处：《中国实用神经疾病杂志》2017年第12期11-14,共4页Chinese Journal of Practical Nervous Diseases

基　　金：2014年度新乡市重点科技攻关计划项目(编号:ZG14007)

摘　　要：目的探讨氟西汀对脑卒中后抑郁患者海马氢质子磁共振波谱(~1 H-MRS)影响的特点。方法以60例脑卒中后抑郁患者为研究组,研究组给予氟西汀抗抑郁治疗8周,以62名脑卒中患者为对照组。采用~1 H-MRS检测脑卒中后抑郁患者(研究组)治疗前后及脑卒中患者(对照组)双侧海马的N-乙酰基天门冬氨酸(NAA)、胆碱复合物(Cho)与肌酸复合物(Cr),以NAA/Cr值和Cho/Cr值进行统计分析。结果研究组治疗前后左右侧海马NAA/Cr值(分别为1.22±0.31和1.19±0.42,1.46±0.35和1.43±0.41)均低于对照组(分别为1.69±0.33和1.66±0.47),差异有统计学意义(均P<0.05);研究组治疗前后左右侧海马Cho/Cr值(分别为1.58±0.39和1.59±0.46,1.55±0.43和1.53±0.42)高于对照组(分别为1.26±0.42和1.31±0.47),差异有统计学意义(均P<0.05);研究组治疗后左右侧海马NAA/Cr值(分别为1.46±0.35和1.43±0.41)均高于治疗前(分别为1.22±0.31和1.19±0.42),差异有统计学意义(均P<0.05)。结论氟西汀可能改变脑卒中后抑郁患者海马神经元的代谢异常。Objective To explore the features of fluoxetine＆#39;＆#39;s effect on hydrogen proton magnetic resonance spectroscopy（1H-MRS） of hippocampus in patients with post-stroke depression.Methods A total of 60 cases with post-stroke depression were collected as research group and were given fluoxetine for 8 weeks,and 62 cases with stroke were selected as control group.The levels of N-asparaginic acid （NAA）,choline compound （Cho） and creatine compound （Cr） were detected by using 1H-MRS and then the ratios of NAA to Cr （NAA/Cr） and of Cho to Cr （Cho/Cr） were calculated.Results In left and right hippocampus before and after treatment,the NAA/Cr ratios in the research group （1.22±0.31 and 1.19±0.42,1.46±0.35 and 1.43±0.41） were higher than those in the control group （1.69±0.33 and 1.66±0.47）,and the differences were significant （all P〈0.05）.Similarly,the Cho/Cr ratios of left and right hippocampus before and after treatment in the research group （1.58±0.39 and 1.59±0.46,1.55±0.43 and 1.53±0.42） showed higher ratio than those in the control group （1.26±0.42 and 1.31±0.47）,and the differences were significant （all P〈0.05）.Additionally,in the research group,the NAA/Cr ratios in bilateral hippocampus after treatment （1.46±0.35 and 1.43±0.41） were higher than those before treatment （1.22±0.31 and 1.19±0.42）,and the differences were significant （all P〈0.05）.Conclusion Fluoxetine may change the abnormal metabolism of bilateral hippocampal neurons in post-stroke depression patients.

关 键 词：氟西汀 脑卒中后抑郁 磁共振波谱学 海马 

分 类 号：R743.3[医药卫生—神经病学与精神病学]