阴囊Paget病与湿疹皮损反射式共聚焦显微镜图像对比分析  

Comparative analysis of reflectance confocal microscopy features between Paget＇s disease and eczema on the scrotum

作　　者：顾安康[1] 张峻岭[2] 孔祥君[2] 刘玉洁[2] 肖尹[1] 纪华安[1] Gu Ankang Zhang Junling Kong Xiangjun Liu Yujie Xiao Yin Ji Hua＇an(Department of Pathology, Tianfin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China Department of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China)

机构地区：[1]天津市中医药研究院附属医院病理科,300120 [2]天津市中医药研究院附属医院皮肤科,300120

出　　处：《中华皮肤科杂志》2017年第7期521-523,共3页Chinese Journal of Dermatology

摘　　要：目的分析比较阴囊Paget病与湿疹皮损在反射式共聚焦显微镜（RCM）下的影像特征。方法对5例临床怀疑为阴囊Paget病和5例阴囊湿疹男性患者的皮损进行RCM扫描，再取该处皮损行组织病理检查，对比分析两者RCM图像与组织病理表现。结果5例Paget病患者，RCM图像可见表皮结构紊乱，正常的蜂窝状结构消失，棘层内可见单个或成巢分布的Paget样细胞。5例阴囊湿疹患者RCM扫描显示棘细胞间水肿，可见网状变性的水疱，偶见脓疱形成。结论阴囊Paget病RCM影像特征与阴囊湿疹明显不同，应用RCM筛查有利于Paget病的早期诊断。Objective To analyze and compare reflectance confocal microscopy （RCM） features between Paget＇s disease and eczema on the scrotum. Methods RCM was performed to image scrota1 lesions of 5 male patients with suspected Paget＇s disease and 5 male patients with eczema. Then, the scrotal lesions were resected and subjected to histopathological examination, and a comparison was conducted between the confocal microscopic and pathological findings. Results RCM imaging for the 5 cases of Paget＇s disease showed disorganized epidermal structure, absence of normal honeycomb structures, single or clustered pagetoid cells in the prickle cell layer. RCM imaging for the 5 cases of eczema showed intercellular edema in the prickle cell layer, reticular degeneration of blisters in all the cases, and pustule formation in some cases. Conclusion RCM features are obviously different between Paget＇s disease of the scrotum and scrotal eczema, so RCM imaging can facilitate the early diagnosis of Paget＇s disease.

关 键 词：佩吉特病 乳腺外 湿疹 阴囊 显微镜检查 共焦 

分 类 号：R737.26[医药卫生—肿瘤]