1,25(OH)2D3对变应性鼻炎作用机制的研究进展  

The regulatory mechanisms of 1,25(OH)2D3 in allergic rhinitis

作　　者：檀静怡 刘涛[1] 

机构地区：[1]山西医科大学第一临床医学院,太原030000

出　　处：《临床耳鼻咽喉头颈外科杂志》2017年第13期1047-1050,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：鼻黏膜含大量血管及腺体,又是整个机体黏膜免疫系统——黏膜相关淋巴样组织的主要部位之一,这种特点使其成为一精细、敏感和活跃的终末器官。变应性鼻炎（allergic rhinitis,AR）是鼻黏膜的一种变态反应性炎症[1]。从免疫学角度来看,AR是一系列细胞间相互作用,最终导致Th2〉Th1反应。“变态反应中的Th2假说”认为,Th2细胞可以释放重要的细胞因子（GM-CSF、IL-4、IL-5、IL-6、IL-13）及趋化因子（巨噬细胞源趋化因子）,在AR发病机制中起到举足轻重的作用[2]。AR患病率在全世界范围内日益升高,但治疗效果仍不尽人意,它可发生于任何年龄,社会负担巨大。Summary Nearly 30 years at home and abroad, the study found that Vitamin D can adjust congenital and acquired immune at the same time. As a result, Vitamin D is expected to be used for prevention and treatment of al- lergic rhinitis. But about vitamin D supplement to the mechanism of action of allergic disease such as allergic rbini tis is still not clear, there is no consistent condusion, even some of the result also has certain contradiction, so vitamin D is not routinely used for clinical therapy. This review will help us to understand the mechanism of action of vitamin D for allergic rhinitis in the treatment of thinking in the future.

关 键 词：鼻炎 变应性 1 25二羟基维生素D3 树突状细胞 T细胞 白介素-10 

分 类 号：R739.6[医药卫生—肿瘤]