大黄红藤消炎方佐治急性胰腺炎的临床研究  

Clinical Investigation on Dahuang Hongteng Anti-Inflammatory Decoction as Supportive Therapy in Patients of Acute Pancreatitis

作　　者：陈玉梅[1] 闫玉红[1] 尹学敬 王丽华[1] 邢佳[1] 

机构地区：[1]哈励逊国际和平医院,河北衡水053000

出　　处：《中华中医药学刊》2017年第7期1910-1913,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：衡水市科研基金项目(15012)

摘　　要：目的:探讨中药方剂大黄红藤消炎方对急性胰腺炎的治疗作用。方法:选取哈励逊国际和平医院消化内科2015年1月—2016年9月收住的急性胰腺炎患者140例,采用随机对照设计原则,依据随机数字表将140例患者随机分为对照组70例及实验组70例。对照组患者采用西医常规方法;实验组患者在对照组治疗方案基础上加用大黄红藤消炎方,两组疗程均12 d。观察治疗前、治疗后7 d及12 d APACHEⅡ评分,监测血淀粉酶、白细胞及血浆C反应蛋白恢复正常时间,腹痛缓解时间、腹胀缓解时间,第1次自主排便时间,评价临床疗效。结果:两组患者治疗前APACHEⅡ评分无统计学差异(P>0.05),治疗7 d后、12 d后APACHEⅡ评分均降低(P<0.05),且实验组降低幅度更显著(P<0.05);实验组患者的血淀粉酶、白细胞、血浆C反应蛋白恢复正常时间均短于对照组患者(P<0.05);实验组患者的腹痛缓解时间及腹胀缓解时间均比对照组有所缩短(均P<0.05),且第1次自主排便时间也明显短于对照组(P<0.01)。结论:急性胰腺炎患者联合应用大黄红藤消炎方可以有效改善APACHEⅡ评分,缩短血淀粉酶、白细胞及血浆C反应蛋白恢复正常时间,较早缓解腹部症状。Objective ： To investigate the therapeutic effects of Dahuang Hongteng Anti - Inflammatory Decoction in a- cute pancreatitis. Methods ：A total of 140 hospital patients with acute pancreatitis from January 2015 to September 2016 in Gastroenterology Department of Harrison International Peace Hospital were selected and randomly divided into the obser- vation group and the control group, 49 case in each group. The patients in control group were treated by routine western medicine. The patients in experiment group were based on the same treatment plus Dahuang Hongteng Anti - Inflammato- ry Decoction. Two groups were treated for 12 days. The patients were tested with APACHE II score pre therapy and 7 day, 12 day after treatment. The time of serum amylase, white blood cell （WBC） and plasma C reactive protein （CRP） recovery, abdominal pain and distention relief and first dejection were observed in two groups. Results ： There was no sig- nificant difference between the two groups （ P 〉 0.05 ） on APACHE II score. The APACHE II score decreased in both groups pre therapy and 7 -day, 12 -day after treatment（ P 〈0. 05 ）and it was more obvious in experiment group com- pared with the control group（ P 〈 0. 05 ）. The experiment group＇ s time for serum amylase, WBC and CRP coming back to normal are all - shorter than that of control group（ P 〈 0.05 ）. The experiment group＇ s time for alleviating bellyache and distention relief were all shorter than that of control group （ P 〈 0. 05 ） while the time for first dejection was also shorter than that of control group （ P 〈 0. 01 ）. Cnclusion： Treatment of routine western medicine combined with Dahuang Hongteng Anti - Inflammatory Decoction can improve the APACHE II score effectively, decrease the time for serum amyl- ase, WBC and CRP coming back to normal and relieve abdominal symptoms earlier.

关 键 词：急性胰腺炎 中药方剂 大黄红藤消炎方 治疗作用 

分 类 号：R576[医药卫生—消化系统]