调强放疗同步卡培他滨治疗老年食管癌的临床研究  

Clinical Research of Intensity Modulated Radiotherapy Combined with Capecitabine in the Treatment of Elderly Patients with Esophageal Cancer

作　　者：陈广家 黄德波[1] CHEN Guang-jia HUANG De-bo(Tai＇an Cancer Hospital, Tai＇an271000, China)

机构地区：[1]山东省泰安市肿瘤防治院,山东泰安271000

出　　处：《中国医学创新》2017年第19期1-4,共4页Medical Innovation of China

基　　金：泰安市科技发展计划项目(2015NS1127)

摘　　要：目的:探讨调强放疗(IMRT)同步单药卡培他滨化疗在老年食管癌中的有效性及安全性。方法:2009年1月-2013年2月入组了30例年龄≥65岁的老年初诊食管癌患者,给予调强放疗,放疗剂量为60Gy,2Gy/次,共30次,每周5次。同时口服卡培他滨(850 mg/m2,2次/d),贯穿整个放疗过程。研究的主要终点为客观缓解率(ORR),次要终点为无进展生存期(PFS)、总生存期(OS)及安全性。疗效评价标准采用RECIST 1.1,毒副反应的评价标准依据CTCAE 4.0。结果:25例患者完成了治疗计划,客观缓解率(ORR)为83.3%。中位PFS为12.5个月,中位OS为18.0个月。1年生存率为76.7%,2年生存率为40.0%,3年生存率为23.3%。≥3级的主要毒性反应包括食管炎(16.7%)及血小板减少症(13.3%)。结论:老年食管癌患者IMRT同步卡培他滨化疗耐受性良好,疗效满意,是一种有前景的治疗方案,值得临床推广应用。Objective： To investigate the efficacy and safety of intensity modulated radiotherapy （ IMRT ） combined with Capecitabine in elderly esophageal cancer.Method ： Thirty patients （ ≥ 65 years old ） with previously untreated esophageal cancer were enrolled from January 2009 to February 2013.The patients were given IMRT, with a dose of 60 Gy, 2 Gy/time, 30 times, 5 times a week, patients accepted Capecitabine （ 850 mg/m2 ） twice one day, throughout the course of treatment.The primary endpoint was objective response rate （ ORR ）, the secondary endpoint was progression-free survival （ PFS ）, overall survival （ OS ） and safety.Response to radiochemotherapy was assessed by RECIST 1.1 and toxicity was evaluated by CTCAE 4.0.Result： 25 cases completed the treatment course, the objective response rate was 83.3%.The median progression-free survival was 12.5 months , and the median survival was 18.0 months.The surrvival rate of one, two and three years were 76.7%, 40.0% and 23.3%, respectively.Grade 3 or more major toxicity consisted esophagitis （ 16.7% ） and thrombocytopenia （ 13.3% ） . Conclusion： IMRT combined with Capecitabine chemotherapy is well tolerated and effective in elderly patients with esophageal cancer, it is a promising treatment plan and worthy of clinical application.

关 键 词：食管癌 放射治疗 化学治疗 卡培他滨 

分 类 号：R735.1[医药卫生—肿瘤]