血清胱抑素C与缺血性卒中患者脑血管造影下脑动脉狭窄的关系  

The interrelation between the serum cystatin C and cerebral artery stenosis in patiens with cerebral ischemic stroke

作　　者：张红梅[1] 杜大勇[2] 石艳超[1] 孟虹媛[1] 李元培[1] 王新平 张东菊[1] 

机构地区：[1]天津港口医院神经内科,天津300456 [2]天津泰达医院神经内科,天津300456 [3]天津环湖医院神经内科,天津300350

出　　处：《中风与神经疾病杂志》2017年第6期491-493,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨缺血性卒中患者胱抑素C(cystatin C,Cys C)与脑动脉粥样硬化性狭窄的关系。方法应用荷兰Philips公司生产的FD-20 C型臂血管造影系统,对299例缺血性卒中患者进行全脑血管造影及血浆Cys C检测,根据Cys C检测水平,分为对照组(Cys C正常)139例患者与异常组(Cys C异常)160例患者,比较其全脑血管造影。结果正常组(对照组)与异常组(病例组)脑动脉狭窄程度差异有统计学意义(χ2=16.94,P<0.05);异常组中颅内外动脉中重度狭窄和闭塞的比率显著升高,且以无侧支循环代偿(73.13%)及弥漫性病变(65.63%)为主;随着Cys C的升高,脑动脉狭窄程度逐渐加重。结论 Cys C是缺血性脑卒中患者脑动脉粥样硬化性狭窄的一种危险因素,脑血管狭窄与Cys C升高有关,Cys C在一定程度上反映脑血管狭窄程度。Objective To explore the relationship between the cystatin C and cerebral atherosclerotic stenosis in patients with cerebral ischemic stroke. Methods For all 299 cases of ischemic cerebrovascular patients,cerebral angiography was performed by FD-20 C-arm angiography system which produced by the Dutch company Philips,and serum Cys C was detected. According to the levels of Cys C,all patients were divided into normal Cys C group（ control group,n = 139） and high Cys C group（ case group,n = 160）,and then analyze the results of cerebral angiography between two groups. Results The differences of cerebral artery stenosis between the control group and case group were statistically significant（ χ2=16. 94,P〈 0. 05）. There were more cases of moderate-severe cerebral artery stenosis and occlusion in the case group than the control group. The majority of vascular involvement in the case group was diffuse without collateral circulation（ 65. 63%and 73. 13%）. With the increase of Cys C,the cerebral artery stenosis aggravated gradually. Conclusion Cys C may be a risk factor for cerebral artery stenosis in ischemic cerebrovascular disease,cerebral vascular stenosis is related with Cys C,which can reflect the severity of cerebral artery stenosis to some extent.

关 键 词：缺血性卒中 胱抑素C 脑动脉狭窄 

分 类 号：R743.3[医药卫生—神经病学与精神病学]