遗忘型与血管型轻度认知功能损害患者神经心理特征比较  被引量:3

Comparison of neuropsychological characteristics inpatients with amnestic and vascular mild cognitive impairment

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作  者:骆雄[1] 唐牟尼[1] 苏婵 李英[1] 陈建平[1] 佘生林 黄若燕[1] 邹灿芳 刘文淘 饶冬萍[1] 郁俊昌[1] 韩海英[1] 

机构地区:[1]广州医科大学附属脑科医院(广州市惠爱医院)老年精神科,510370

出  处:《中华老年医学杂志》2017年第7期750-754,共5页Chinese Journal of Geriatrics

摘  要:目的比较遗忘型与血管型轻度认知功能损害(MCI)患者的神经心理特征差异。方法分析297例诊断为遗忘型(AMCI,258例)及血管型(VMCI,39例)社区MCI老年人的蒙特利尔认知评估量表(MoCA)、简明精神状态量表(MMSE)、听觉词语学习测验(AVLT)、临床痴呆评定量表(CDR)、社会功能评定量表(FAQ)、改良Hachinski缺血评分量表(M-HIS)及流调中心用抑郁量表(CES-DC)等神经心理评估结果。结果AMCI组/VMCI组的MaCA总分[(9.63±5.17)分比(9.98±6.02)分]、MMSE总分[(16.90±4.84)分比(16.90±6.19)分]、AVLT即刻记忆[(2.35±1.39)分比(2.91±1.84)分]、AVLT延迟回忆[(2.23±2.09)分比(2.47±2.20)分]、AVLT延迟再认[(7.33±3.98)分比(6.85±4.02)分]、CDR总分(0.5/0.5)等差异无统计学意义(均P〉0.05)。MoCA测量时,AMCI组/VMCI组的视空间与执行[(0.71±1.02)分比(0.92±1.26)分]、语青[(0.34±0.56)分比(0.50±0.80)分],抽象思维[(0.25±0.49)分比(0.15±0.43)分],差异有统计学意义(P〈0.05);MMSE测量时各认知领域功能评分2组差异无统计学意义。AMCI组jVMCI组的CES~DC评分[(1.75±4.27)分比(2.76±6.72)分]、FAQ评分[(4.42±4.66)分比(8.71±7.03)分]、M—HIS评分[(0.40±0.64)分比(7.59±3.53)分],差异有统计学意义(P〈70.05)。结论遗忘型与血管型MCI患者总体认知受损程度无明显差别,但遗忘型MCI患者的视空间与执行、语言等认知功能受损更重,血管型MCI患者的抽象思维、社会功能受损更重及伴有更多的抑郁症状。Objective To identify the differences inneuropsychological characteristics between amnestic(AMCI) and vascular mild cognitive impairment (VMCI) . Methods Totally 297 old community residents with mild cognitive impairment(MCI)were divided into amnestic MCI(AMCI)and vascular MCI(VMCI)subgroup from Guangzhou MCI prevalence survey. The elderly with MCI were interviewed and tested with the Chinese version of Montreal Cognitive Assessment(MoCA),the Mini- Mental state examination ( MMSE), Auditory Verbal Learning Test ( AVLT), the Clinical Dementia Rating scale(CDR),Functional Activity Questionnaire(FAQ), the Modified H achinski Ischemic Scale (M-HIS) ,Center for Epidemiologic Studies(CES-DC)to evaluate neuropsychological characteristics. Results AMCI versus VMCI group showed that the total scores of MoCA were(9.63±5.17 vs. 9.98 ±6.02) ,total scores of MMSE were(16.90±4.84 vs. 16.90±6.19),AVLT immediate memory was (2.35±1.39 vs. 2.91±1.84) ,AVLT delayed recall was(2.28±2.09 vs. 2.47±2.20) ,AVLT delayed recognition was(7.33±3.98 vs. 6.85±4.02)and total scores of CDR(0.5 vs. 0.5) ,with no differences between the 2 groups (all P〉0.05).Based on MoCA survey, AMCI versus VMCI group showed statistically significant differences(all P〈0.05 )in parameters of visual space and execution(0.71 ± 1.02 vs. 0. 92±1.26),language function(0. 34±0.56 vs. 0.50±0. 80)and abstract thinking(0.25± 0.49 vs. 0.15±0.43),but based on MMSE survey,no difference was found in the various cognitive domains between the two groups. The AMCI versus VMCI group showed statistically significantdifferences(all P〈.0.05) in parameters of CES-DC scale(1.75±4.27 vs. 2.76 ± 6.72), FAQ scale (4.42±4.66 vs. 8.71±7.03),M-HIS scale(0.40±0.64 vs. 7.59±3.53). Conclusions There is no significant difference in general cognitive impairment between AMCI and VMCI, but the visual space and execution,language function are more impaired in AMCI

关 键 词:认知障碍 神经心理学测验 遗忘 血管 

分 类 号:R749.1[医药卫生—神经病学与精神病学]

 

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