IgA肾病早期无创检查的相关研究进展  

Research Progress of Noninvasive Examination of Early IgA Nephropathy

作　　者：章永[1] 罗军[1] 胡斌[1] 王娟[1] 曹婷婷[1] 欧阳艳[1] 

机构地区：[1]三峡大学仁和医院肾内科,湖北宜昌443003

出　　处：《医学综述》2017年第13期2572-2575,共4页Medical Recapitulate

基　　金：湖北省教育厅自然科学研究计划(D20131305);三峡大学人才科研启动基金(KJ2011B080)

摘　　要：IgA肾病是我国最常见的原发性肾脏疾病,是引起终末期肾衰竭的重要原因之一。以往IgA肾病的早期诊断主要依赖于肾活检,但肾活检不仅有创、费用高、有相对和绝对禁忌证,而且有较高的风险。近年来关于IgA肾病早期无创性检查的研究较多,尤其是随着尿液分析技术(中性粒细胞明胶酶相关载脂蛋白、肾损伤分子1、N-乙酰-β-D-氨基葡萄糖苷酶、尿蛋白质组学)和影像学检查手段(磁共振血氧水平依赖成像、声触诊组织定量分析、彩色多普勒超声组织动态灌注测量技术)的不断提高,IgA肾病在早期进行无创检查成为了可能。IgA nephropathy is the most common primary renal disease in China and the important reason causing the end-stage renal failure. Early diagnosis of IgA nephropathy mainly relies on renal biopsy, but it is featured with invasive, high cost and with relative and absolute contraindications and high risk. In recent years ,the research on non-invasive exami- nation associated with the early stage of IgA nephropathy has made a remarkable progress, especially with the development of urine analysis technique （ neutrophil gelatinase associated lipocalin, kidney injury molecule-I, N-acety-beta-D-giucosamini- dase, urinary proteomics）and imaging examination（ magnetic resonance imaging-blood oxygen level dependent imaging, vir- tual touch quantization, dynamic tissue perfusion measurement ）, noninvasive examination becomes possible.

关 键 词：IG A肾病 早期 无创检查 尿液分析技术 

分 类 号：R692.31[医药卫生—泌尿科学]