SD大鼠肾脏非肿瘤自发病变分析  

Analysis of spontaneous non-tumor lesions in the kidney of SD rats

作　　者：高洪彬[1] 宋向荣[1] 黄振烈[1] 蔡婷峰[1] 陆丰荣[1] 殷霄[1] 陈晓燕[1] 马超亚[1] 黄曼琪 郑杰蔚 谢植伟[1] 曾丽海[1] 梁旻炜 陈润涛[1] 

机构地区：[1]广东省职业病防治院,广东省职业病防治院重点实验室,广东广州510300

出　　处：《中国职业医学》2017年第3期266-269,共4页China Occupational Medicine

基　　金：广东省医学科学技术研究基金(A2016122);广东省职业病防治重点实验室(2012A061400007)

摘　　要：目的探讨不同周龄和性别的SD大鼠肾脏非肿瘤病变发生情况。方法收集亚急性毒性实验、亚慢性毒性实验、1年及2年慢性毒性与致癌合并实验中空白对照组的无特定病原体级SD大鼠800只,按实验结束时大鼠周龄分别分为10、19、56和108周龄组,每组雌、雄大鼠各100只。于各自实验终末期分别处死大鼠后取肾脏组织,计算肾脏脏器系数,分析大鼠肾脏非肿瘤性病理改变情况。结果雌性大鼠肾脏脏器系数在56、108周龄组均低于10和19周龄组(P<0.008);雄性大鼠肾脏脏器系数在56周龄组分别低于10和19周龄组(P<0.008),在108周龄组高于56周龄组(P<0.008);108周龄组雄性大鼠肾脏脏器系数高于108周龄组雌性大鼠(P<0.008)。与108周龄组雄性大鼠比较,108周龄组雌性大鼠肾小管钙盐沉积、间质炎细胞浸润及肾小管扩张发生率升高(P<0.05),慢性进行性肾病发生率下降(P<0.01);56周龄组雌性大鼠肾小管钙盐沉积发生率高于56周龄组雄性大鼠(P<0.01)。结论 SD大鼠肾脏非肿瘤自发性病变较多见,相同周龄组不同性别大鼠间部分病变的发生率不同。Objective To explore the spontaneous non-tumor lesion of kidney and its correlation with different age and sex in SD rats.Methods Eight hundred specific pathogen free SD rats were collected from the blank control groups used in subacute toxicity tests, subchronic toxicity tests and 1 or 2 years of chronic toxicity combined with carcinogenic tests.Rats were randomly divided into 4 groups with 10, 19, 56 or 108 weeks of experimental periods.Each group consisted of 100 female and 100 male rats.The renal tissues were collected at the end of each experiment, and the renal organ coefficients were calculated.The pathological non-tumor changes of the kidneys were analyzed.Results The renal organ coefficients in female rats at the age of 56 and 108 weeks were both lower than that of 10 and 19 weeks （P〈0.008）.The renal organ coefficient of male rats at the age of 56 weeks was lower than that of 10 and 19 weeks （P〈0.008）.The renal organ coefficient of male rats at the age of 108 weeks was higher than that of 56 weeks （P〈0.008）.The renal organ coefficient of male rats at the age of 108 weeks was higher than that of female rats of 108 weeks （P〈0.008）.The incidence of renal tubular calcium salt deposition, interstitial inflammatory cell infiltration and renal tubular dilatation in the female rats at the age of 108 weeks were higher than those in the male rats at the age of 108 weeks （P〈0.05）.The chronic progressive nephropathy incidence of female rats at the age of 108 weeks was lower than that of male rats aged 108 weeks （P〈0.01）.The renal tubular calcium salt deposition incidence of female rats aged 56 weeks was higher than that of male rats aged 56 weeks （P〈0.01）.Conclusion The spontaneous non-tumor lesions in the kidney of SD rats were common.The incidence of some lesions was different in the same age group with different sex.

关 键 词：大鼠 肾脏 非肿瘤病变 脏器系数 发生率 

分 类 号：R737.9[医药卫生—肿瘤] R114[医药卫生—临床医学]