氟西汀预防卒中后抑郁的有效性  

Prophylactic efficiency of fluoxetine for poststroke depression

作　　者：徐红波[1] 邵伟华[2] 熊桂兰[1] 杨立磊 张海钢[1] 吴京兰[1] 

机构地区：[1]深圳市南山区人民医院重症医学科,广东深圳518026 [2]重庆医科大学附属第一医院

出　　处：《包头医学院学报》2017年第7期1-3,17,共4页Journal of Baotou Medical College

基　　金：深圳市卫生计生系统科研项目(201507078);国家自然科学基金青年基金(31300881)

摘　　要：目的:系统评价氟西汀预防卒中后抑郁的有效性。方法:检索Pubmed,Embase,Cocharane Library,CBM,CNKI,VIP,以及万方等数据库中关于氟西汀预防卒中后抑郁的随机对照试验,时间截止至2016年10月8日,两名研究成员根据设定的标准独立的进行文献筛选和数据提取,并进行质量评价。结果:共纳入6篇随机对照试验,Meta分析结果显示较对照组相比,氟西汀可降低卒中后抑郁发生率[RR=0.29(95%CI=0.18~0.45),P=0.000];不良反应方面,氟西汀组与对照组之间差异无统计学意义(P>0.05)。结论:氟西汀可降低卒中后抑郁发生率,具有较好的安全性和耐受性。Objective：To systematically assess the prophylactic efficiency of fluoxetine for poststroke depression （PSD）. Methods：Studies evaluating prophylactic efficiency of fluoxetine for PSI） were systematically retrieved in Pubmed, Emhase, Cocharane Library,CBM,CNKI,VIP,and Wanfang database from inception to October 8th 2016. Two reviewers independently screened literatures, extracted data, and assessed the risk of bias of included studies. Results：Six studies were randomly included. The results of meta - analysis showed that fluoxetine could significantly decrease the incidence of PSD compared with that in control group [ RR = 0.29 （95 % CI = 0. 18 -0.45 ）, P = 0.000 ]. There was no significant difference of adverse reactions between fluoxetine group and control group （ P 〉 0.05 ） . Conclusion： Fluoxetine is effective for the prophylaxis of PSD and has good safety and tolerance.

关 键 词：卒中后抑郁 氟西汀 预防 META分析 

分 类 号：R743.3[医药卫生—神经病学与精神病学]